Al\u00e9m da artrite e do envelhecimento prematuro. Novos testes revogam a verdade \u2013 entre duvidas e suspeitas \u2013 sobre a vida e a morte de ovelhas Dolly, o primeiro mam\u00edfero nascido para a clonagem. Para falar pela primeira vez os raios-X do pr\u00f3prio Dolly, o primeiro mam\u00edfero de clonagem, sua filha Bonnie, o primog\u00eanito de quatro filhos, e Megan e Morag, as ovelhas clonadas de c\u00e9lulas cultivadas no laborat\u00f3rio. Publicado na revista Scientific Reports, o estudo \u00e9 baseado em pesquisadores liderados por Kevin Sinclair da British University of Nottingham. A not\u00edcia de que Dolly sofreu artrite na perna traseira esquerda foi dada em 2003, quando a ovelha tinha 5 anos e meio de idade e suscitou preocupa\u00e7\u00f5es e d\u00favidas sobre a sa\u00fade dos animais clonados e seu poss\u00edvel envelhecimento precoce.
\nComo nenhum dos raios-X originais de Dolly foi preservado, os pesquisadores decidiram fazer os esqueletos das quatro ovelhas, todos mantidos no Museu Nacional da Esc\u00f3cia em Edimburgo. Descobriu-se que Dolly n\u00e3o tinha envelhecido cedo: ele n\u00e3o tinha artrite, e a condi\u00e7\u00e3o de suas articula\u00e7\u00f5es era semelhante \u00e0 dos pares concebidos naturalmente. Pouco mais de um ano depois, uma doen\u00e7a pulmonar irrevers\u00edvel tornou necess\u00e1rio suprimir isso para evitar o sofrimento. Bonnie e Megan, que eram mais velhas, apresentavam sinais artr\u00edticos m\u00faltiplos, mas, nesse caso, os vest\u00edgios de inflama\u00e7\u00e3o n\u00e3o eram diferentes dos normalmente observados em ovelhas mais velhas.<\/p>\n
Oltre all’artrite e all’invecchiamento precoce. Nuovi test revocano la verit\u00e0 – tra dubbi e sospetti – sulla vita e la morte delle pecore Dolly, il primo mammifero nato per la clonazione. Per parlare per la prima volta delle radiografie di Dolly stesso, il primo mammifero di clonazione, sua figlia Bonnie, la maggiore di quattro figli, e Megan e Morag, la pecora clonata di cellule cresciute in laboratorio. Pubblicato nella rivista Scientific Reports, lo studio \u00e8 basato su ricercatori guidati da Kevin Sinclair della British University of Nottingham. La notizia che Dolly soffriva di artrite alla zampa posteriore sinistra fu data nel 2003 quando la pecora aveva 5 anni e mezzo e sollev\u00f2 preoccupazioni e dubbi sulla salute degli animali clonati e sul loro possibile invecchiamento precoce.
\nPoich\u00e9 nessuna delle radiografie originali di Dolly \u00e8 stata conservata, i ricercatori hanno deciso di realizzare gli scheletri delle quattro pecore, tutte conservate al National Museum of Scotland di Edimburgo. Risult\u00f2 che Dolly non era invecchiata in anticipo: non aveva l’artrite e le sue articolazioni erano simili a quelle delle coppie naturalmente concepite. Poco pi\u00f9 di un anno dopo, la malattia polmonare irreversibile rese necessario sopprimerla per evitare la sofferenza. Bonnie e Megan, che erano pi\u00f9 anziani, avevano pi\u00f9 segni artritici, ma in questo caso le tracce di infiammazione non erano diverse da quelle comunemente osservate nelle pecore pi\u00f9 anziane.<\/p>\n
In addition to arthritis and premature aging. New tests revoke the truth – between doubts and suspicions – about the life and death of sheep Dolly, the first mammal born for cloning. To speak for the first time the X-rays of Dolly himself, the first mammal of cloning, his daughter Bonnie, the eldest of four children, and Megan and Morag, the cloned sheep of cells grown in the laboratory. Published in the journal Scientific Reports, the study is based on researchers led by Kevin Sinclair of the British University of Nottingham. The news that Dolly suffered arthritis in the left hind leg was given in 2003 when the sheep was 5 \u00bd years old and raised concerns and doubts about the health of the cloned animals and their possible premature aging.
\nAs none of Dolly’s original X-rays were preserved, the researchers decided to make the skeletons of the four sheep, all kept at the National Museum of Scotland in Edinburgh. It turned out that Dolly had not aged early: he had no arthritis, and the condition of his joints was similar to that of naturally conceived pairs. Just over a year later, irreversible lung disease made it necessary to suppress this to avoid suffering. Bonnie and Megan, who were older, had multiple arthritic signs, but in this case the traces of inflammation were no different from those commonly seen in older sheep.<\/p>\n
Adem\u00e1s de la artritis y el envejecimiento prematuro. Las nuevas pruebas revocan la verdad -entre dudas y sospechas- sobre la vida y la muerte de ovejas Dolly, el primer mam\u00edfero nacido para la clonaci\u00f3n. Para hablar por primera vez los rayos X del propio Dolly, el primer mam\u00edfero de clonaci\u00f3n, su hija Bonnie, el primog\u00e9nito de cuatro hijos, y Megan y Morag, las ovejas clonadas de c\u00e9lulas cultivadas en el laboratorio. Publicado en la revista Scientific Reports, el estudio se basa en investigadores liderados por Kevin Sinclair de la British University of Nottingham. La noticia de que Dolly sufri\u00f3 artritis en la pierna trasera izquierda fue dada en 2003, cuando la oveja ten\u00eda 5 a\u00f1os y medio de edad y suscit\u00f3 preocupaciones y dudas sobre la salud de los animales clonados y su posible envejecimiento precoz.
\nComo ninguno de los rayos X originales de Dolly fue preservado, los investigadores decidieron hacer los esqueletos de las cuatro ovejas, todos mantenidos en el Museo Nacional de Escocia en Edimburgo. Se descubri\u00f3 que Dolly no hab\u00eda envejecido temprano: \u00e9l no ten\u00eda artritis, y la condici\u00f3n de sus articulaciones era similar a la de los pares concebidos naturalmente. Poco m\u00e1s de un a\u00f1o despu\u00e9s, una enfermedad pulmonar irreversible hizo necesario suprimirlo para evitar el sufrimiento. Bonnie y Megan, que eran m\u00e1s viejos, presentaban signos artr\u00edticos m\u00faltiples, pero en ese caso, los vestigios de inflamaci\u00f3n no eran diferentes de los normalmente observados en ovejas m\u00e1s viejas.<\/p>\n
En plus de l’arthrite et du vieillissement pr\u00e9matur\u00e9. De nouveaux tests r\u00e9v\u00e8lent la v\u00e9rit\u00e9 – entre doutes et suspicions – sur la vie et la mort du mouton Dolly, le premier mammif\u00e8re n\u00e9 pour le clonage. Pour parler pour la premi\u00e8re fois des rayons X de Dolly, premier mammif\u00e8re du clonage, de sa fille Bonnie, l’a\u00een\u00e9e de quatre enfants, et de Megan et Morag, la brebis clon\u00e9e de cellules cultiv\u00e9es en laboratoire. Publi\u00e9e dans la revue Scientific Reports, cette \u00e9tude s\u2019appuie sur des chercheurs dirig\u00e9s par Kevin Sinclair de la British University of Nottingham. La nouvelle que Dolly souffrait d’arthrite \u00e0 la patte arri\u00e8re gauche a \u00e9t\u00e9 annonc\u00e9e en 2003, alors que le mouton avait 5 ans et demi. Elle suscitait des inqui\u00e9tudes et des doutes quant \u00e0 la sant\u00e9 des animaux clon\u00e9s et \u00e0 leur vieillissement pr\u00e9matur\u00e9 possible.
\nComme aucune des radiographies d’origine de Dolly n’a \u00e9t\u00e9 pr\u00e9serv\u00e9e, les chercheurs ont d\u00e9cid\u00e9 de fabriquer les squelettes des quatre moutons, tous conserv\u00e9s au Mus\u00e9e national d’\u00c9cosse \u00e0 \u00c9dimbourg. Il s’est av\u00e9r\u00e9 que Dolly n’avait pas vieilli t\u00f4t: il ne souffrait pas d’arthrite et l’\u00e9tat de ses articulations \u00e9tait semblable \u00e0 celui de paires con\u00e7ues naturellement. Un peu plus d’un an plus tard, une maladie pulmonaire irr\u00e9versible a rendu n\u00e9cessaire la suppression de cette maladie pour \u00e9viter les souffrances. Bonnie et Megan, qui \u00e9taient plus \u00e2g\u00e9es, pr\u00e9sentaient de multiples signes arthritiques, mais dans ce cas, les traces d’inflammation n’\u00e9taient pas diff\u00e9rentes de celles que l’on observe couramment chez les moutons plus \u00e2g\u00e9s.<\/p>\n
Neben Arthritis und vorzeitigem Altern. Neue Tests entziehen der Wahrheit – zwischen Zweifeln und Verdacht – das Leben und den Tod von Schaf Dolly, dem ersten S\u00e4ugetier, das zum Klonen geboren wurde. Zum ersten Mal die R\u00f6ntgenbilder von Dolly, dem ersten S\u00e4ugetier des Klonens, zu sprechen, seine Tochter Bonnie, die \u00e4lteste von vier Kindern, und Megan und Morag, die geklonten Schafe der im Labor gez\u00fcchteten Zellen. Die in der Zeitschrift Scientific Reports ver\u00f6ffentlichte Studie basiert auf Forschern, die von Kevin Sinclair von der British University of Nottingham geleitet werden. Die Nachricht, dass Dolly an Arthritis im linken Hinterbein litt, wurde im Jahr 2003 gegeben, als das Schaf 5 \u00bd Jahre alt war, und es wurden Bedenken und Zweifel hinsichtlich der Gesundheit der geklonten Tiere und ihrer m\u00f6glichen vorzeitigen Alterung ausgel\u00f6st.
\nDa keine der urspr\u00fcnglichen R\u00f6ntgenaufnahmen von Dolly erhalten blieb, beschlossen die Forscher, die Skelette der vier Schafe herzustellen, die alle im National Museum of Scotland in Edinburgh aufbewahrt werden. Es stellte sich heraus, dass Dolly nicht fr\u00fch gealtert war: Er hatte keine Arthritis und der Zustand seiner Gelenke war dem von nat\u00fcrlich vorgestellten Paaren \u00e4hnlich. Etwas mehr als ein Jahr sp\u00e4ter machte es eine irreversible Lungenerkrankung notwendig, dies zu unterdr\u00fccken, um Leiden zu vermeiden. Bonnie und Megan, die \u00e4lter waren, hatten mehrere arthritische Anzeichen, aber in diesem Fall unterschieden sich die Entz\u00fcndungsspuren nicht von denen, die gew\u00f6hnlich bei \u00e4lteren Schafen beobachtet werden.<\/p>\n
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Al\u00e9m da artrite e do envelhecimento prematuro. Novos testes revogam a verdade \u2013 entre duvidas […]<\/p>\n","protected":false},"author":315,"featured_media":13121,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-13122","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/www.42doit.com\/en\/wp-json\/wp\/v2\/posts\/13122","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.42doit.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.42doit.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.42doit.com\/en\/wp-json\/wp\/v2\/users\/315"}],"replies":[{"embeddable":true,"href":"https:\/\/www.42doit.com\/en\/wp-json\/wp\/v2\/comments?post=13122"}],"version-history":[{"count":0,"href":"https:\/\/www.42doit.com\/en\/wp-json\/wp\/v2\/posts\/13122\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.42doit.com\/en\/wp-json\/wp\/v2\/media\/13121"}],"wp:attachment":[{"href":"https:\/\/www.42doit.com\/en\/wp-json\/wp\/v2\/media?parent=13122"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.42doit.com\/en\/wp-json\/wp\/v2\/categories?post=13122"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.42doit.com\/en\/wp-json\/wp\/v2\/tags?post=13122"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}