Prader-Willi syndrome is a rare genetic disorder that presents with a wide variety of symptoms, from hypotonia, muscle tone problems, to hyperphagia, which results in an important appetite responsible for the development of obesity, the main cause of death of those suffering from this condition. Here’s what you need to know about Prader-Willi syndrome.<\/p>\n
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Prader-Willi, what is the syndrome<\/strong> <\/p>\n The symptoms of Prader-Willi<\/strong> <\/p>\n Dying of Prader-Willi: obesity risk<\/strong> <\/p>\n Diagnosis and treatment of Prader-Willi<\/strong> Prader-Willi, la rara enfermedad gen\u00e9tica que hace que las personas se vuelvan obesas hasta que mueren: qu\u00e9 son, s\u00edntomas y tratamiento<\/strong><\/p>\n <\/p>\n El s\u00edndrome de Prader-Willi es un raro trastorno gen\u00e9tico que se presenta con una amplia variedad de s\u00edntomas, desde hipoton\u00eda, problemas del tono muscular hasta hiperfagia, lo que resulta en un importante apetito responsable del desarrollo de la obesidad, la principal causa de muerte. de quienes padecen esta condici\u00f3n. Esto es lo que necesita saber sobre el s\u00edndrome de Prader-Willi.<\/p>\n <\/p>\n Prader-Willi, \u00bfcu\u00e1l es el s\u00edndrome?<\/strong> <\/p>\n Los s\u00edntomas de Prader-Willi<\/strong> <\/p>\n Morir de Prader-Willi: riesgo de obesidad<\/strong> <\/p>\n Diagn\u00f3stico y tratamiento de Prader-Willi<\/strong> Prader-Willi, la maladie g\u00e9n\u00e9tique rare qui rend les personnes ob\u00e8ses jusqu’\u00e0 leur mort: nature, sympt\u00f4mes et traitement<\/strong><\/p>\n Le syndrome de Prader-Willi est une maladie g\u00e9n\u00e9tique rare qui se manifeste par une grande vari\u00e9t\u00e9 de sympt\u00f4mes, allant de l\u2019hypotonie aux probl\u00e8mes de tonus musculaire, en passant par l\u2019hyperphagie, qui entra\u00eene un important app\u00e9tit responsable du d\u00e9veloppement de l\u2019ob\u00e9sit\u00e9, principale cause de d\u00e9c\u00e8s. de ceux qui souffrent de cette condition. Voici ce que vous devez savoir sur le syndrome de Prader-Willi.<\/p>\n <\/p>\n Prader-Willi, quel est le syndrome<\/strong> <\/p>\n Les sympt\u00f4mes de Prader-Willi<\/strong> <\/p>\n Mourir de Prader-Willi: risque d’ob\u00e9sit\u00e9<\/strong> <\/p>\n Diagnostic et traitement de Prader-Willi<\/strong> Prader-Willi, a doen\u00e7a gen\u00e9tica rara que torna as pessoas obesas at\u00e9 morrerem: o que s\u00e3o, sintomas e tratamento<\/strong><\/p>\n A s\u00edndrome de Prader-Willi \u00e9 um dist\u00farbio gen\u00e9tico raro que apresenta uma ampla variedade de sintomas, desde hipotonia, problemas de t\u00f4nus \u200b\u200bmuscular at\u00e9 hiperfagia, que resulta em um importante apetite respons\u00e1vel pelo desenvolvimento da obesidade, a principal causa de morte daqueles que sofrem desta condi\u00e7\u00e3o. Veja o que voc\u00ea precisa saber sobre a s\u00edndrome de Prader-Willi.<\/p>\n <\/p>\n Prader-Willi, qual \u00e9 a s\u00edndrome<\/strong> <\/p>\n Os sintomas de Prader-Willi<\/strong> <\/p>\n Morte de Prader-Willi: risco de obesidade<\/strong> <\/p>\n Diagn\u00f3stico e tratamento de Prader-Willi<\/strong> Prader-Willi\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u9057\u4f20\u6027\u75be\u75c5\uff0c\u5b83\u4f7f\u4eba\u4eec\u5728\u6b7b\u524d\u53d8\u5f97\u80a5\u80d6\uff1a\u5b83\u4eec\u662f\u4ec0\u4e48\uff0c\u75c7\u72b6\u548c\u6cbb\u7597\u65b9\u6cd5<\/strong><\/p>\n Prader-Willi\u7efc\u5408\u5f81\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u9057\u4f20\u6027\u75be\u75c5\uff0c\u8868\u73b0\u51fa\u5404\u79cd\u5404\u6837\u7684\u75c7\u72b6\uff0c\u4ece\u808c\u5f20\u529b\u51cf\u9000\uff0c\u808c\u5f20\u529b\u95ee\u9898\u5230\u98df\u6b32\u8fc7\u76db\uff0c\u5bfc\u81f4\u80a5\u80d6\u7684\u91cd\u8981\u98df\u6b32\uff0c\u5bfc\u81f4\u80a5\u80d6\uff0c\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u90a3\u4e9b\u60a3\u6709\u8fd9\u79cd\u75c5\u75c7\u7684\u4eba\u3002\u4ee5\u4e0b\u662f\u60a8\u9700\u8981\u4e86\u89e3\u7684\u5173\u4e8ePrader-Willi\u7efc\u5408\u5f81\u7684\u4fe1\u606f<\/p>\n <\/p>\n Prader-Willi\uff0c\u8fd9\u662f\u4ec0\u4e48\u7efc\u5408\u75c7<\/strong> <\/p>\n Prader-Willi\u7684\u75c7\u72b6<\/strong> <\/p>\n Prader-Willi\u6b7b\u4ea1\uff1a\u80a5\u80d6\u98ce\u9669<\/strong> Prader-Willi\u7684\u8bca\u65ad\u548c\u6cbb\u7597 Prader-Willi \u060c \u0627\u0644\u0645\u0631\u0636 \u0627\u0644\u0648\u0631\u0627\u062b\u064a \u0627\u0644\u0646\u0627\u062f\u0631 \u0627\u0644\u0630\u064a \u064a\u062c\u0639\u0644 \u0627\u0644\u0646\u0627\u0633 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0627\u0644\u0633\u0645\u0646\u0629 \u0627\u0644\u0645\u0641\u0631\u0637\u0629 \u062d\u062a\u0649 \u064a\u0645\u0648\u062a\u0648\u0627: \u0645\u0627 \u0647\u064a \u0639\u0644\u064a\u0647 \u060c \u0648\u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0648\u0627\u0644\u0639\u0644\u0627\u062c<\/p>\n \u062a\u0639\u062f \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0628\u0631\u0627\u062f\u0631 \u0648\u064a\u0644\u064a \u0627\u0636\u0637\u0631\u0627\u0628\u064b\u0627 \u0648\u0631\u0627\u062b\u064a\u064b\u0627 \u0646\u0627\u062f\u0631\u064b\u0627 \u064a\u062a\u0633\u0628\u0628 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u062a\u0646\u0648\u0639\u0629 \u0645\u0646 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u060c \u0645\u0646 \u0646\u0642\u0635 \u0627\u0644\u062a\u0648\u062a\u0631 \u0627\u0644\u0639\u0636\u0644\u064a \u060c \u0648\u0645\u0634\u0627\u0643\u0644 \u0641\u064a \u0644\u0648\u0646 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u060c \u0625\u0644\u0649 \u0641\u0631\u0637 \u0627\u0644\u0628\u0644\u0639 \u060c \u0645\u0645\u0627<\/p>\n \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0634\u0647\u064a\u0629 \u0645\u0647\u0645\u0629 \u0645\u0633\u0624\u0648\u0644\u0629 \u0639\u0646 \u062a\u0637\u0648\u0631 \u0627\u0644\u0633\u0645\u0646\u0629 \u060c \u0648\u0627\u0644\u0633\u0628\u0628 \u0627\u0644\u0631\u0626\u064a\u0633\u064a \u0644\u0644\u0648\u0641\u0627\u0629 \u0645\u0646 \u0623\u0648\u0644\u0626\u0643 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0647\u0630\u0627 \u0627\u0644\u0634\u0631\u0637. \u0625\u0644\u064a\u0643 \u0645\u0627 \u062a\u062d\u062a\u0627\u062c \u0644\u0645\u0639\u0631\u0641\u062a\u0647 \u062d\u0648\u0644 \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0628\u0631\u0627\u062f\u0631 \u0648\u064a\u0644\u064a<\/p>\n \u0628\u0631\u0627\u062f\u0631 \u0648\u064a\u0644\u064a \u060c \u0645\u0627 \u0647\u064a \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0623\u0639\u0631\u0627\u0636 \u0628\u0631\u0627\u062f\u0631 \u0648\u064a\u0644\u064a \u0645\u0648\u062a \u0628\u0631\u0627\u062f\u0631 \u0648\u064a\u0644\u064a: \u062e\u0637\u0631 \u0627\u0644\u0633\u0645\u0646\u0629 \u062a\u0634\u062e\u064a\u0635 \u0648\u0639\u0644\u0627\u062c \u0628\u0631\u0627\u062f\u0631 \u0648\u064a\u0644\u064a Prader-Willi syndrome is a rare genetic disorder that presents with a wide variety of symptoms, […]<\/p>\n","protected":false},"author":305,"featured_media":13727,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[4268],"tags":[],"class_list":["post-13730","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-en"],"_links":{"self":[{"href":"https:\/\/www.42doit.com\/en\/wp-json\/wp\/v2\/posts\/13730","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.42doit.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.42doit.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.42doit.com\/en\/wp-json\/wp\/v2\/users\/305"}],"replies":[{"embeddable":true,"href":"https:\/\/www.42doit.com\/en\/wp-json\/wp\/v2\/comments?post=13730"}],"version-history":[{"count":1,"href":"https:\/\/www.42doit.com\/en\/wp-json\/wp\/v2\/posts\/13730\/revisions"}],"predecessor-version":[{"id":19853,"href":"https:\/\/www.42doit.com\/en\/wp-json\/wp\/v2\/posts\/13730\/revisions\/19853"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.42doit.com\/en\/wp-json\/wp\/v2\/media\/13727"}],"wp:attachment":[{"href":"https:\/\/www.42doit.com\/en\/wp-json\/wp\/v2\/media?parent=13730"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.42doit.com\/en\/wp-json\/wp\/v2\/categories?post=13730"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.42doit.com\/en\/wp-json\/wp\/v2\/tags?post=13730"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nIt is called Prader-Willi syndrome and is a rare genetic disease that presents with hypothalamic-pituitary abnormalities, ie abnormalities affecting the hypothalamus and the pituitary gland. The abnormality of this condition is on chromosome 15 and affects one in 25,000 people.<\/p>\n
\nThe typical symptoms of Prader-Willi are hypotonia, that is the lack of muscle tone, particularly in the neo-natal period, which is followed by hyperphagia in the first two years of life, and therefore an increase in the sensation of appetite that leads to the development of obesity even at an early age. The disease is also associated with behavioral disorders, such as obsessive-compulsive disorder, and psychiatric disorders, with symptoms similar to those typical of the autism spectrum disorder. You can also list some facial features that determine Prader-Willi as the “narrow forehead, almond-shaped eyes, the thin upper lip and the downward mouth, scoliosis or small hands and feet”, and also low stature and incomplete development pubertal.<\/p>\n
\nObesity is the main cause of patient mortality, in fact it occurs following hyperphagia and, in a short time, it can become serious to the point of compromising the patient’s survival.<\/p>\n
\nThe diagnosis to date is performed with clinical criteria and genetic analysis, a test can verify the 15q11-q13 region to identify anomalies. As for treatment, to date it does not exist, what can be done is to intervene with treatments aimed at the symptoms, such as hypotonia and hyperphagia, but also delays in growth, for example by administering the growth hormone.<\/p>\n
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\nSe llama s\u00edndrome de Prader-Willi y es una enfermedad gen\u00e9tica rara que se presenta con anomal\u00edas hipotal\u00e1micas-hipofisarias, es decir, anomal\u00edas que afectan al hipot\u00e1lamo y la gl\u00e1ndula pituitaria. La anomal\u00eda de esta condici\u00f3n se encuentra en el cromosoma 15 y afecta a una de cada 25,000 personas.<\/p>\n
\nLos s\u00edntomas t\u00edpicos de Prader-Willi son hipoton\u00eda, es decir, la falta de tono muscular, especialmente en el per\u00edodo neonatal, que se acompa\u00f1a de hiperfagia en los primeros dos a\u00f1os de vida y, por lo tanto, un aumento en la sensaci\u00f3n de apetito que conduce a Para el desarrollo de la obesidad, incluso a una edad temprana. La enfermedad tambi\u00e9n se asocia con trastornos del comportamiento, como el trastorno obsesivo-compulsivo y los trastornos psiqui\u00e1tricos, con s\u00edntomas similares a los t\u00edpicos del trastorno del espectro autista. Tambi\u00e9n puede enumerar algunas caracter\u00edsticas faciales que determinan Prader-Willi como la “frente estrecha, los ojos en forma de almendra, el labio superior delgado y la boca hacia abajo, la escoliosis o las manos y los pies peque\u00f1os”, as\u00ed como la baja estatura y el desarrollo incompleto puberal.<\/p>\n
\nLa obesidad es la principal causa de mortalidad del paciente, de hecho, se produce despu\u00e9s de la hiperfagia y, en poco tiempo, puede llegar a ser grave hasta el punto de comprometer la supervivencia del paciente.<\/p>\n
\nEl diagn\u00f3stico hasta la fecha se realiza con criterios cl\u00ednicos y an\u00e1lisis gen\u00e9ticos, una prueba puede verificar la regi\u00f3n 15q11-q13 para identificar anomal\u00edas. En cuanto al tratamiento, hasta la fecha no existe, lo que se puede hacer es intervenir con tratamientos dirigidos a los s\u00edntomas, como hipoton\u00eda e hiperfagia, pero tambi\u00e9n retrasos en el crecimiento, por ejemplo, administrando la hormona del crecimiento.<\/p>\n
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\nC’est ce qu’on appelle le syndrome de Prader-Willi. Il s’agit d’une maladie g\u00e9n\u00e9tique rare caract\u00e9ris\u00e9e par des anomalies hypothalamo-hypophysaires, c’est-\u00e0-dire des anomalies affectant l’hypothalamus et l’hypophyse. L’anomalie de cette maladie concerne le chromosome 15 et touche une personne sur 25 000.<\/p>\n
\nLes sympt\u00f4mes typiques de Prader-Willi sont une hypotonie, c’est-\u00e0-dire un manque de tonus musculaire, en particulier au cours de la p\u00e9riode n\u00e9onatale, qui est suivie d’une hyperphagie au cours des deux premi\u00e8res ann\u00e9es de la vie et, par cons\u00e9quent, d’une augmentation de la sensation d’app\u00e9tit au d\u00e9veloppement de l’ob\u00e9sit\u00e9, m\u00eame \u00e0 un \u00e2ge pr\u00e9coce. La maladie est \u00e9galement associ\u00e9e \u00e0 des troubles du comportement, tels que le trouble obsessionnel-compulsif, et des troubles psychiatriques, avec des sympt\u00f4mes similaires \u00e0 ceux typiques du trouble du spectre de l’autisme. Vous pouvez \u00e9galement \u00e9num\u00e9rer certains traits du visage qui d\u00e9terminent Prader-Willi, tels que “le front \u00e9troit, les yeux en amande, la l\u00e8vre sup\u00e9rieure et la bouche baiss\u00e9es, la scoliose ou les petites mains et les pieds”, ainsi que la petite taille et le d\u00e9veloppement incomplet. pubertaire.<\/p>\n
\nL’ob\u00e9sit\u00e9 est la principale cause de mortalit\u00e9 chez les patients. En fait, elle survient apr\u00e8s une hyperphagie et, en peu de temps, elle peut devenir grave au point de compromettre la survie du patient.<\/p>\n
\nLe diagnostic \u00e0 ce jour est effectu\u00e9 avec des crit\u00e8res cliniques et une analyse g\u00e9n\u00e9tique. Un test permet de v\u00e9rifier la r\u00e9gion 15q11-q13 pour identifier les anomalies. Pour ce qui est du traitement, il n\u2019existe pas \u00e0 ce jour; on peut intervenir avec des traitements ciblant les sympt\u00f4mes, tels que l\u2019hypotonie et l\u2019hyperphagie, mais aussi des retards de croissance, par exemple en administrant l\u2019hormone de croissance.<\/p>\n
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\n\u00c9 chamada s\u00edndrome de Prader-Willi e \u00e9 uma doen\u00e7a gen\u00e9tica rara que apresenta anormalidades hipotal\u00e2mico-pituit\u00e1rias, ou seja, anormalidades que afetam o hipot\u00e1lamo e a gl\u00e2ndula pituit\u00e1ria. A anormalidade dessa condi\u00e7\u00e3o est\u00e1 no cromossomo 15 e afeta uma em 25.000 pessoas.<\/p>\n
\nOs sintomas t\u00edpicos de Prader-Willi s\u00e3o a hipotonia, que \u00e9 a falta de t\u00f4nus \u200b\u200bmuscular, particularmente no per\u00edodo neonatal, que \u00e9 seguido por hiperfagia nos dois primeiros anos de vida e, portanto, um aumento na sensa\u00e7\u00e3o de apetite que leva para o desenvolvimento da obesidade, mesmo em tenra idade. A doen\u00e7a tamb\u00e9m est\u00e1 associada a dist\u00farbios comportamentais, como transtorno obsessivo-compulsivo e transtornos psiqui\u00e1tricos, com sintomas semelhantes aos t\u00edpicos do espectro autista. Voc\u00ea tamb\u00e9m pode listar algumas caracter\u00edsticas faciais que determinam Prader-Willi como “testa estreita, olhos amendoados, l\u00e1bio superior fino e boca descendente, escoliose ou m\u00e3os e p\u00e9s pequenos”, e tamb\u00e9m baixa estatura e desenvolvimento incompleto. puberal.<\/p>\n
\nA obesidade \u00e9 a principal causa de mortalidade do paciente, na verdade ocorre ap\u00f3s a hiperfagia e, em pouco tempo, pode se tornar grave a ponto de comprometer a sobrevida do paciente.<\/p>\n
\nO diagn\u00f3stico at\u00e9 o momento \u00e9 realizado com crit\u00e9rios cl\u00ednicos e an\u00e1lise gen\u00e9tica, um teste pode verificar a regi\u00e3o 15q11-q13 para identificar anomalias. Quanto ao tratamento, at\u00e9 \u00e0 data n\u00e3o existe, o que pode ser feito \u00e9 intervir com tratamentos que visem os sintomas, tais como hipotonia e hiperfagia, mas tamb\u00e9m atrasos no crescimento, por exemplo administrando a hormona do crescimento.<\/p>\n
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\n\u5b83\u88ab\u79f0\u4e3aPrader-Willi\u7efc\u5408\u5f81\uff0c\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u9057\u4f20\u6027\u75be\u75c5\uff0c\u8868\u73b0\u4e3a\u4e0b\u4e18\u8111 – \u5782\u4f53\u5f02\u5e38\uff0c\u5373\u5f71\u54cd\u4e0b\u4e18\u8111\u548c\u5782\u4f53\u7684\u5f02\u5e38\u3002\u8fd9\u79cd\u60c5\u51b5\u7684\u5f02\u5e38\u53d1\u751f\u572815\u53f7\u67d3\u8272\u4f53\u4e0a\uff0c\u5f71\u54cd\u4e8625,000\u4eba\u4e2d\u7684\u4e00\u4e2a\u3002<\/p>\n
\nPrader-Willi\u7684\u5178\u578b\u75c7\u72b6\u662f\u808c\u5f20\u529b\u51cf\u9000\uff0c\u5373\u7f3a\u4e4f\u808c\u5f20\u529b\uff0c\u7279\u522b\u662f\u5728\u65b0\u751f\u513f\u671f\uff0c\u968f\u540e\u51fa\u73b0\u5934\u4e24\u5e74\u7684\u98df\u6b32\u8fc7\u76db\uff0c\u56e0\u6b64\u5bfc\u81f4\u98df\u6b32\u589e\u52a0\u3002\u751a\u81f3\u5728\u5f88\u5c0f\u7684\u65f6\u5019\u5c31\u5f00\u59cb\u80a5\u80d6\u3002\u8be5\u75be\u75c5\u8fd8\u4e0e\u884c\u4e3a\u969c\u788d\u6709\u5173\uff0c\u4f8b\u5982\u5f3a\u8feb\u75c7\u548c\u7cbe\u795e\u969c\u788d\uff0c\u5176\u75c7\u72b6\u7c7b\u4f3c\u4e8e\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u7684\u5178\u578b\u75c7\u72b6\u3002\u60a8\u8fd8\u53ef\u4ee5\u5217\u51fa\u4e00\u4e9b\u9762\u90e8\u7279\u5f81\uff0c\u5c06Prader-Willi\u5b9a\u4e49\u4e3a\u201c\u524d\u989d\u72ed\u7a84\uff0c\u773c\u775b\u5448\u674f\u4ec1\u72b6\uff0c\u4e0a\u5507\u8584\uff0c\u4e0b\u988c\uff0c\u810a\u67f1\u4fa7\u5f2f\u6216\u5c0f\u624b\u811a\u201d\uff0c\u8eab\u6750\u77ee\u5c0f\uff0c\u53d1\u80b2\u4e0d\u5168\u9752\u6625\u671f\u3002<\/p>\n
\n\u80a5\u80d6\u662f\u60a3\u8005\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u5b9e\u9645\u4e0a\u5b83\u53d1\u751f\u5728\u98df\u6b32\u8fc7\u76db\u4e4b\u540e\uff0c\u5e76\u4e14\u5728\u5f88\u77ed\u7684\u65f6\u95f4\u5185\uff0c\u5b83\u53ef\u80fd\u53d8\u5f97\u4e25\u91cd\u5230\u5371\u53ca\u60a3\u8005\u7684\u751f\u5b58\u3002<\/p>\n
\n\u8fc4\u4eca\u4e3a\u6b62\u7684\u8bca\u65ad\u662f\u901a\u8fc7\u4e34\u5e8a\u6807\u51c6\u548c\u9057\u4f20\u5206\u6790\u8fdb\u884c\u7684\uff0c\u6d4b\u8bd5\u53ef\u4ee5\u9a8c\u8bc115q11-q13\u533a\u57df\u4ee5\u8bc6\u522b\u5f02\u5e38\u3002\u81f3\u4e8e\u6cbb\u7597\uff0c\u8fc4\u4eca\u4e3a\u6b62\u5b83\u4e0d\u5b58\u5728\uff0c\u53ef\u4ee5\u505a\u7684\u662f\u5e72\u9884\u9488\u5bf9\u75c7\u72b6\u7684\u6cbb\u7597\uff0c\u4f8b\u5982\u808c\u5f20\u529b\u51cf\u9000\u548c\u98df\u6b32\u8fc7\u76db\uff0c\u4f46\u4e5f\u5ef6\u8fdf\u751f\u957f\uff0c\u4f8b\u5982\u901a\u8fc7\u65bd\u7528\u751f\u957f\u6fc0\u7d20\u3002<\/p>\n
\n
\n\u0648\u064a\u0633\u0645\u0649 \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0628\u0631\u0627\u062f\u0631 \u0648\u064a\u0644\u064a \u0648\u0647\u0648 \u0645\u0631\u0636 \u0648\u0631\u0627\u062b\u064a \u0646\u0627\u062f\u0631 \u064a\u0635\u064a\u0628\u0647 \u0634\u0630\u0648\u0630 \u0641\u064a \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0646\u062e\u0627\u0645\u064a\u0629 \u060c \u0623\u064a \u062a\u0634\u0648\u0647\u0627\u062a \u062a\u0635\u064a\u0628 \u0645\u0646\u0637\u0642\u0629 \u0645\u0627 \u062a\u062d\u062a \u0627\u0644\u0645\u0647\u0627\u062f \u0648\u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0646\u062e\u0627\u0645\u064a\u0629. \u062a\u0634\u0648\u0647\u0627\u062a \u0647\u0630\u0627 \u0627\u0644\u0634\u0631\u0637 \u0645\u0648\u062c\u0648\u062f\u0629 \u0641\u064a \u0627\u0644\u0643\u0631\u0648\u0645\u0648\u0633\u0648\u0645 15 \u0648\u062a\u0624\u062b\u0631 \u0639\u0644\u0649 \u0634\u062e\u0635 \u0645\u0646 \u0628\u064a\u0646 \u0643\u0644 25000 \u0634\u062e\u0635.<\/p>\n
\n\u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u0646\u0645\u0648\u0630\u062c\u064a\u0629 \u0644\u0640 Prader-Willi \u0647\u064a \u0646\u0642\u0635 \u0627\u0644\u062a\u0648\u062a\u0631 \u060c \u0648\u0647\u0630\u0627 \u0647\u0648 \u0646\u0642\u0635 \u0644\u0648\u0646 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u060c \u0648\u062e\u0627\u0635\u0629 \u0641\u064a \u0641\u062a\u0631\u0629 \u0627\u0644\u0648\u0644\u0627\u062f\u0629 \u0627\u0644\u062d\u062f\u064a\u062b\u0629 \u060c \u0648\u0627\u0644\u062a\u064a \u062a\u0644\u064a\u0647\u0627 \u0641\u0631\u0637 \u0627\u0644\u0628\u0644\u0639 \u0641\u064a \u0623\u0648\u0644 \u0639\u0627\u0645\u064a\u0646 \u0645\u0646 \u0627\u0644\u062d\u064a\u0627\u0629 \u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u0632\u064a\u0627\u062f\u0629 \u0641\u064a \u0627\u0644\u0625\u062d\u0633\u0627\u0633 \u0628\u0627\u0644\u0634\u0647\u064a\u0629 \u0627\u0644\u0630\u064a \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u062a\u0637\u0648\u0631 \u0627\u0644\u0633\u0645\u0646\u0629 \u062d\u062a\u0649 \u0641\u064a \u0633\u0646 \u0645\u0628\u0643\u0631\u0629. \u064a\u0631\u062a\u0628\u0637 \u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0636 \u0623\u064a\u0636\u064b\u0627 \u0628\u0627\u0644\u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u0633\u0644\u0648\u0643\u064a\u0629 \u060c \u0645\u062b\u0644 \u0627\u0636\u0637\u0631\u0627\u0628 \u0627\u0644\u0648\u0633\u0648\u0627\u0633 \u0627\u0644\u0642\u0647\u0631\u064a \u060c \u0648\u0627\u0644\u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u0646\u0641\u0633\u064a\u0629 \u060c \u0645\u0639 \u0623\u0639\u0631\u0627\u0636 \u0645\u0634\u0627\u0628\u0647\u0629 \u0644\u062a\u0644\u0643 \u0627\u0644\u0634\u0627\u0626\u0639\u0629 \u0641\u064a \u0627\u0636\u0637\u0631\u0627\u0628 \u0637\u064a\u0641 \u0627\u0644\u062a\u0648\u062d\u062f. \u064a\u0645\u0643\u0646\u0643 \u0623\u064a\u0636\u064b\u0627 \u0633\u0631\u062f \u0628\u0639\u0636 \u0645\u064a\u0632\u0627\u062a \u0627\u0644\u0648\u062c\u0647 \u0627\u0644\u062a\u064a \u062a\u062d\u062f\u062f Prader-Willi \u0639\u0644\u0649 \u0623\u0646\u0647\u0627 “\u0627\u0644\u062c\u0628\u0647\u0629 \u0627\u0644\u0636\u064a\u0642\u0629 \u060c \u0639\u064a\u0648\u0646 \u0627\u0644\u0644\u0648\u0632 \u060c \u0627\u0644\u0634\u0641\u0629 \u0627\u0644\u0639\u0644\u064a\u0627 \u0627\u0644\u0631\u0641\u064a\u0639\u0629 \u0648\u0627\u0644\u0641\u0645 \u0627\u0644\u0633\u0641\u0644\u064a \u060c \u0627\u0644\u062c\u0646\u0641 \u0623\u0648 \u0627\u0644\u064a\u062f\u064a\u0646 \u0648\u0627\u0644\u0642\u062f\u0645\u064a\u0646 \u0627\u0644\u0635\u063a\u064a\u0631\u0629” \u060c \u0648\u0623\u064a\u0636\u064b\u0627 \u0642\u0627\u0645\u0629 \u0645\u0646\u062e\u0641\u0636\u0629 \u0648\u062a\u0637\u0648\u0631 \u063a\u064a\u0631 \u0645\u0643\u062a\u0645\u0644 \u0627\u0644\u0628\u0644\u0648\u063a.<\/p>\n
\n\u0627\u0644\u0633\u0645\u0646\u0629 \u0647\u064a \u0627\u0644\u0633\u0628\u0628 \u0627\u0644\u0631\u0626\u064a\u0633\u064a \u0644\u0648\u0641\u064a\u0627\u062a \u0627\u0644\u0645\u0631\u0636\u0649 \u060c \u0641\u064a \u0627\u0644\u0648\u0627\u0642\u0639 \u062a\u062d\u062f\u062b \u0628\u0639\u062f \u0641\u0631\u0637 \u0627\u0644\u0628\u0644\u0639 \u060c \u0648\u0641\u064a \u0648\u0642\u062a \u0642\u0635\u064a\u0631 \u060c \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0635\u0628\u062d \u062e\u0637\u064a\u0631\u0629 \u0644\u062f\u0631\u062c\u0629 \u062a\u0639\u0631\u064a\u0636 \u0628\u0642\u0627\u0621 \u0627\u0644\u0645\u0631\u064a\u0636 \u0644\u0644\u062e\u0637\u0631.<\/p>\n
\n\u064a\u062a\u0645 \u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u062a\u0634\u062e\u064a\u0635 \u062d\u062a\u0649 \u0627\u0644\u0622\u0646 \u0648\u0641\u0642\u064b\u0627 \u0644\u0644\u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0648\u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u062c\u064a\u0646\u064a \u060c \u064a\u0645\u0643\u0646 \u0644\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u062a\u062d\u0642\u0642 \u0645\u0646 \u0645\u0646\u0637\u0642\u0629 15q11-q13 \u0644\u062a\u062d\u062f\u064a\u062f \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0627\u0644\u0634\u0627\u0630\u0629. \u0623\u0645\u0627 \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0644\u0639\u0644\u0627\u062c \u060c \u0641\u0625\u0646\u0647 \u063a\u064a\u0631 \u0645\u0648\u062c\u0648\u062f \u062d\u062a\u0649 \u0627\u0644\u0622\u0646 \u060c \u0645\u0627 \u064a\u0645\u0643\u0646 \u0641\u0639\u0644\u0647 \u0647\u0648 \u0627\u0644\u062a\u062f\u062e\u0644 \u0641\u064a \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0633\u062a\u0647\u062f\u0641 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u060c \u0645\u062b\u0644 \u0646\u0642\u0635 \u0627\u0644\u062a\u0648\u062a\u0631 \u0648\u0641\u0631\u0637 \u0627\u0644\u0628\u0644\u0639 \u060c \u0648\u0643\u0630\u0644\u0643 \u062a\u0623\u062e\u0631 \u0627\u0644\u0646\u0645\u0648 \u060c \u0639\u0644\u0649 \u0633\u0628\u064a\u0644 \u0627\u0644\u0645\u062b\u0627\u0644 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0625\u0639\u0637\u0627\u0621 \u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0646\u0645\u0648.<\/p>\n","protected":false},"excerpt":{"rendered":"