{"id":14898,"date":"2020-03-24T18:36:55","date_gmt":"2020-03-24T17:36:55","guid":{"rendered":"https:\/\/www.42doit.com\/science-en\/coronavirus-the-point-on-experimental-drugs\/"},"modified":"2020-03-24T18:36:55","modified_gmt":"2020-03-24T17:36:55","slug":"coronavirus-the-point-on-experimental-drugs","status":"publish","type":"post","link":"https:\/\/www.42doit.com\/en\/2020\/03\/24\/coronavirus-the-point-on-experimental-drugs\/","title":{"rendered":"Coronavirus, the point on experimental drugs"},"content":{"rendered":"

At present there are no therapies recommended by the World Health Organization (WHO) for the new coronavirus, and only supportive therapies are indicated in the patient care guidelines, such as oxygen therapy, fluid administration and empirical use of antibiotics to treat any bacterial co-infections. WHO will gather a forum of experts from around the world on 11 and 12 February to discuss how to speed up research on vaccines and possible therapies. However, some patients are using some drugs already in use or experimenting with other diseases, while for others, preclinical tests have started in view of a possible use, in one case also thanks to studies conducted by the Institute.<\/p>\n

Remdesivir: this drug is being tested on humans against Ebola infections, and in vitro tests it has also shown some activity against coronaviruses such as Sars and Mers. It has been used on the first patient infected with the new coronavirus in the United States, as described in Lancet, and trials are being conducted on some 800 patients in some Chinese hospitals.<\/p>\n

Lopinavir and Ritonavir: the combination of these two anti-HIV drugs was used in 2004 during the Sars epidemic, and is being tested on 41 patients in a hospital in Wuhan, together with a dose of alpha interferon.<\/p>\n

Chloroquine: this antimalarial drug has been in use for over 70 years, and recently the Chinese National Health Commission has indicated it among those who have an in vitro activity against the new coronavirus on which tests will continue. Among the first studies to verify its antiretroviral activity, in the case against HIV, one was carried out by researchers from the Istituto Superiore di Sanit\u00e0 coordinated by dr. Andrea Savarino.<\/p>\n

Umifenovir and Darunavir: the former is an anti-flu drug, while the latter is an anti-HIV drug that has been in use for several years. Both would have shown activity against the virus in vitro.<\/p>\n

The phases of a clinical trial<\/strong><\/p>\n

Before being approved, a drug goes through several phases of experimentation, both preclinical and clinical. The first tests are carried out in vitro, in the case of viruses on infected cells. Those showing activity are then tested on animal models. If successful, we move on to the human clinical phase, which is usually divided into three phases. The first, on a small number of healthy people, serves to verify that the potential drug is safe and does not give serious side effects, and can be skipped if, for example, a molecule is used that is already in use for other purposes. In the second, therapy is tested on a limited number of patients, to verify their effectiveness. If this phase is also passed, it passes to the third, on a greater number of sick people.<\/p>\n

Source: https:\/\/www.iss.it<\/p>\n

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Coronavirus, el punto sobre drogas experimentales<\/strong><\/p>\n

En la actualidad no hay terapias recomendadas por la Organizaci\u00f3n Mundial de la Salud (OMS) para el nuevo coronavirus, y solo las terapias de apoyo est\u00e1n indicadas en las pautas de atenci\u00f3n al paciente, como la oxigenoterapia, la administraci\u00f3n de l\u00edquidos y Uso emp\u00edrico de antibi\u00f3ticos para tratar cualquier coinfecci\u00f3n bacteriana. La OMS reunir\u00e1 un foro de expertos de todo el mundo los d\u00edas 11 y 12 de febrero para discutir c\u00f3mo acelerar la investigaci\u00f3n sobre vacunas y posibles terapias. Sin embargo, algunos pacientes est\u00e1n usando algunos medicamentos que ya est\u00e1n en uso o experimentando con otras enfermedades, mientras que para otros, las pruebas precl\u00ednicas han comenzado en vista de un posible uso, en un caso tambi\u00e9n gracias a estudios realizados por el Instituto.<\/p>\n

Remdesivir: este medicamento se est\u00e1 probando en humanos contra las infecciones por el \u00c9bola, y las pruebas in vitro tambi\u00e9n han mostrado cierta actividad contra los coronavirus como Sars y Mers. Se ha utilizado en el primer paciente infectado con el nuevo coronavirus en los Estados Unidos, como se describe en Lancet, y en algunos hospitales chinos se est\u00e1 realizando un experimento con aproximadamente 800 pacientes.<\/p>\n

Lopinavir y Ritonavir: la combinaci\u00f3n de estos dos medicamentos contra el VIH se us\u00f3 en 2004 durante la epidemia de Sars y se est\u00e1 probando en 41 pacientes en un hospital de Wuhan, junto con una dosis de alfa interfer\u00f3n.<\/p>\n

Cloroquina: este medicamento antipal\u00fadico ha estado en uso durante m\u00e1s de 70 a\u00f1os, y recientemente la Comisi\u00f3n Nacional de Salud de China lo ha indicado entre aquellos que tienen una actividad in vitro contra el nuevo coronavirus en el que continuar\u00e1n las pruebas. Entre los primeros estudios para verificar su actividad antirretroviral, en el caso contra el VIH, uno fue realizado por investigadores del Istituto Superiore di Sanit\u00e0 coordinados por el dr. Andrea Savarino.<\/p>\n

Umifenovir y Darunavir: el primero es un medicamento contra la gripe, mientras que el segundo es un medicamento contra el VIH que ha estado en uso durante varios a\u00f1os. Ambos habr\u00edan mostrado actividad contra el virus in vitro.<\/p>\n

Las fases de un ensayo cl\u00ednico.<\/strong><\/p>\n

Antes de ser aprobado, un medicamento pasa por varias fases de experimentaci\u00f3n, tanto precl\u00ednicas como cl\u00ednicas. Las primeras pruebas se llevan a cabo in vitro, en el caso de virus en c\u00e9lulas infectadas. Los que muestran actividad se prueban en modelos animales. Si tiene \u00e9xito, pasamos a la fase cl\u00ednica humana, que generalmente se divide en tres fases. El primero, en un peque\u00f1o n\u00famero de personas sanas, sirve para verificar que el medicamento potencial es seguro y no produce efectos secundarios graves, y puede omitirse si, por ejemplo, se usa una mol\u00e9cula que ya est\u00e1 en uso para otros fines. En el segundo, la terapia se prueba en un n\u00famero limitado de pacientes, para verificar su efectividad. Si esta fase tambi\u00e9n se pasa, pasa a la tercera, en un mayor n\u00famero de personas enfermas.<\/p>\n

Fuente: https:\/\/www.iss.it<\/p>\n

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Coronavirus, il punto sui farmaci in sperimentazione<\/strong><\/p>\n

Al momento non ci sono terapie consigliate dall\u2019Organizzazione mondiale della sanit\u00e0 (Oms) per il nuovo coronavirus, e nelle linee guida sull\u2019assistenza ai pazienti sono indicate solo terapie di supporto, come l\u2019ossigeno-terapia, la somministrazione di fluidi e l\u2019uso empirico di antibiotici per trattare eventuali co-infezioni batteriche. L\u2019Oms riunir\u00e0 l\u201911 e 12 febbraio un forum di esperti da tutto il mondo per discutere di come accelerare la ricerca su vaccini e possibili terapie. Su alcuni pazienti si stanno per\u00f2 utilizzando alcuni farmaci gi\u00e0 in uso o in sperimentazione per altre patologie, mentre per altri sono iniziati i test preclinici in vista di un possibile uso, in un caso anche grazie a studi condotti dall\u2019Istituto.<\/p>\n

Remdesivir: questo farmaco \u00e8 in sperimentazione sull\u2019uomo contro le infezioni da Ebola, e nei test in vitro ha mostrato una certa attivit\u00e0 anche contro coronavirus come Sars e Mers. E\u2019 stato utilizzato sul primo paziente infetto dal nuovo coronavirus negli Usa, come descritto su Lancet, ed in alcuni ospedali cinesi sta partendo una sperimentazione su circa 800 pazienti.<\/p>\n

Lopinavir e Ritonavir: la combinazione di questi due farmaci anti Hiv \u00e8 stata usata nel 2004 durante l\u2019epidemia di Sars, ed \u00e8 in sperimentazione su 41 pazienti in un ospedale di Wuhan, insieme ad una dose di interferone alfa.<\/p>\n

Clorochina: questo farmaco antimalarico \u00e8 in uso da oltre 70 anni, e recentemente la Commissione Sanitaria Nazionale Cinese lo ha indicato tra quelli che hanno un\u2019attivit\u00e0 in vitro contro il nuovo coronavirus su cui proseguiranno i test. Tra i primi studi a verificarne l\u2019attivit\u00e0 antiretrovirale, nella fattispecie contro l\u2019Hiv, uno \u00e8 stato eseguito da ricercatori dell\u2019Istituto Superiore di Sanit\u00e0 coordinati dal dott. Andrea Savarino.<\/p>\n

Umifenovir e Darunavir: il primo \u00e8 un antinfluenzale, mentre il secondo \u00e8 un farmaco anti Hiv gi\u00e0 in uso da diversi anni. Entrambi avrebbero mostrato un\u2019attivit\u00e0 contro il virus in vitro.<\/p>\n

Le fasi di una sperimentazione clinica<\/strong><\/p>\n

Prima di essere approvato un farmaco passa attraverso diverse fasi di sperimentazione, sia di tipo preclinico che clinico. I primi test vengono effettuati in vitro, nel caso dei virus su cellule infettate. Quelle che mostrano attivit\u00e0 vengono poi sperimentate su modelli animali. In caso di successo si passa alla fase clinica sull\u2019uomo, che si divide di solito in tre fasi. La prima, su un numero ristretto di persone sane, serve a verificare che il potenziale farmaco sia sicuro e non dia effetti collaterali gravi, e pu\u00f2 essere saltata nel caso in cui ad esempio si utilizza una molecola che \u00e8 gi\u00e0 in uso per altri scopi. Nella seconda si testa la terapia su un numero limitato di pazienti, per verificarne l\u2019efficacia. Se anche questa fase viene superata si passa alla terza, su un numero maggiore di persone malate.<\/p>\n

Fonte: https:\/\/www.iss.it<\/p>\n

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Coronavirus, le point sur les m\u00e9dicaments exp\u00e9rimentaux<\/strong><\/p>\n

Il n’y a actuellement aucune th\u00e9rapie recommand\u00e9e par l’Organisation mondiale de la sant\u00e9 (OMS) pour le nouveau coronavirus, et seules les th\u00e9rapies de soutien sont indiqu\u00e9es dans les directives de soins aux patients, telles que l’oxyg\u00e9noth\u00e9rapie, l’administration de liquides et utilisation empirique d’antibiotiques pour traiter toute co-infection bact\u00e9rienne. L’OMS r\u00e9unira un forum d’experts du monde entier les 11 et 12 f\u00e9vrier pour discuter des moyens d’acc\u00e9l\u00e9rer la recherche sur les vaccins et les th\u00e9rapies possibles. Cependant, certains patients utilisent des m\u00e9dicaments d\u00e9j\u00e0 utilis\u00e9s ou exp\u00e9rimentent d’autres pathologies, tandis que pour d’autres, des tests pr\u00e9cliniques ont commenc\u00e9 en vue d’une utilisation possible, dans un cas \u00e9galement gr\u00e2ce aux \u00e9tudes men\u00e9es par l’Institut.<\/p>\n

Remdesivir: ce m\u00e9dicament est test\u00e9 sur l’homme contre les infections \u00e0 Ebola, et des tests in vitro ont \u00e9galement montr\u00e9 une certaine activit\u00e9 contre les coronavirus tels que Sars et Mers. Il a \u00e9t\u00e9 utilis\u00e9 sur le premier patient infect\u00e9 par le nouveau coronavirus aux \u00c9tats-Unis, comme d\u00e9crit dans Lancet, et dans certains h\u00f4pitaux chinois, une exp\u00e9rience est en cours sur environ 800 patients.<\/p>\n

Lopinavir et Ritonavir: la combinaison de ces deux m\u00e9dicaments anti-VIH a \u00e9t\u00e9 utilis\u00e9e en 2004 lors de l’\u00e9pid\u00e9mie de Sars et est test\u00e9e sur 41 patients dans un h\u00f4pital de Wuhan, avec une dose d’interf\u00e9ron alpha.<\/p>\n

Chloroquine: ce m\u00e9dicament antipalud\u00e9en est utilis\u00e9 depuis plus de 70 ans, et r\u00e9cemment la Commission nationale de la sant\u00e9 chinoise l’a indiqu\u00e9 parmi ceux qui ont une activit\u00e9 in vitro contre le nouveau coronavirus sur lequel les tests se poursuivront. Parmi les premi\u00e8res \u00e9tudes \u00e0 v\u00e9rifier son activit\u00e9 antir\u00e9trovirale, dans le cas du VIH, une a \u00e9t\u00e9 r\u00e9alis\u00e9e par des chercheurs de l’Istituto Superiore di Sanit\u00e0 coordonn\u00e9 par le dr. Andrea Savarino.<\/p>\n

Umifenovir et Darunavir: le premier est un m\u00e9dicament antigrippal, tandis que le second est un m\u00e9dicament anti-VIH utilis\u00e9 depuis plusieurs ann\u00e9es. Les deux auraient montr\u00e9 une activit\u00e9 contre le virus in vitro.<\/p>\n

Les phases d’un essai clinique<\/strong><\/p>\n

Avant d’\u00eatre approuv\u00e9, un m\u00e9dicament passe par plusieurs phases d’exp\u00e9rimentation, \u00e0 la fois pr\u00e9clinique et clinique. Les premiers tests sont effectu\u00e9s in vitro, dans le cas de virus sur cellules infect\u00e9es. Ceux qui montrent une activit\u00e9 sont ensuite test\u00e9s sur des mod\u00e8les animaux. En cas de succ\u00e8s, nous passons \u00e0 la phase clinique humaine, qui est g\u00e9n\u00e9ralement divis\u00e9e en trois phases. Le premier, sur un petit nombre de personnes en bonne sant\u00e9, sert \u00e0 v\u00e9rifier que le m\u00e9dicament potentiel est s\u00fbr et ne donne pas d’effets secondaires graves, et peut \u00eatre ignor\u00e9 si, par exemple, une mol\u00e9cule est d\u00e9j\u00e0 utilis\u00e9e \u00e0 d’autres fins. Dans le second, la th\u00e9rapie est test\u00e9e sur un nombre limit\u00e9 de patients, pour v\u00e9rifier leur efficacit\u00e9. Si cette phase est \u00e9galement pass\u00e9e, elle passe \u00e0 la troisi\u00e8me, sur un plus grand nombre de malades.<\/p>\n

Source: https:\/\/www.iss.it<\/p>\n

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Coronavirus, der Punkt \u00fcber experimentelle Medikamente<\/strong><\/p>\n

Derzeit gibt es keine von der Weltgesundheitsorganisation (WHO) empfohlenen Therapien f\u00fcr das neue Coronavirus, und in den Richtlinien zur Patientenversorgung sind nur unterst\u00fctzende Therapien angegeben, wie z. B. Sauerstofftherapie, Fl\u00fcssigkeitsverabreichung und empirische Verwendung von Antibiotika zur Behandlung von bakteriellen Koinfektionen. Die WHO wird am 11. und 12. Februar ein Expertenforum aus der ganzen Welt zusammenbringen, um zu er\u00f6rtern, wie die Forschung zu Impfstoffen und m\u00f6glichen Therapien beschleunigt werden kann. Einige Patienten verwenden jedoch einige Medikamente, die bereits verwendet werden, oder experimentieren mit anderen Krankheiten, w\u00e4hrend f\u00fcr andere pr\u00e4klinische Tests im Hinblick auf eine m\u00f6gliche Verwendung begonnen haben, in einem Fall auch dank Studien, die vom Institut durchgef\u00fchrt wurden.<\/p>\n

Remdesivir: Dieses Medikament wird am Menschen gegen Ebola-Infektionen getestet. In-vitro-Tests haben auch eine gewisse Aktivit\u00e4t gegen Coronaviren wie Sars und Mers gezeigt. Es wurde bei dem ersten Patienten angewendet, der in den USA mit dem neuen Coronavirus infiziert war, wie in Lancet beschrieben, und in einigen chinesischen Krankenh\u00e4usern werden Studien mit etwa 800 Patienten durchgef\u00fchrt.<\/p>\n

Lopinavir und Ritonavir: Die Kombination dieser beiden Anti-HIV-Medikamente wurde 2004 w\u00e4hrend der Sars-Epidemie angewendet und wird an 41 Patienten in einem Krankenhaus in Wuhan zusammen mit einer Dosis Alpha-Interferon getestet.<\/p>\n

Chloroquin: Dieses Malariamedikament wird seit \u00fcber 70 Jahren verwendet, und k\u00fcrzlich hat die chinesische nationale Gesundheitskommission es unter denjenigen angegeben, die eine In-vitro-Aktivit\u00e4t gegen das neue Coronavirus haben, an dem die Tests fortgesetzt werden. Unter den ersten Studien zur \u00dcberpr\u00fcfung der antiretroviralen Aktivit\u00e4t im Fall von HIV wurde eine von Forschern des Istituto Superiore di Sanit\u00e0 durchgef\u00fchrt, die von Dr. Andrea Savarino.<\/p>\n

Umifenovir und Darunavir: Ersteres ist ein Anti-Grippe-Medikament, w\u00e4hrend letzteres ein Anti-HIV-Medikament ist, das seit mehreren Jahren angewendet wird. Beide h\u00e4tten in vitro Aktivit\u00e4t gegen das Virus gezeigt.<\/p>\n

Die Phasen einer klinischen Studie<\/strong><\/p>\n

Vor der Zulassung durchl\u00e4uft ein Medikament mehrere pr\u00e4klinische und klinische Experimentierphasen. Die ersten Tests werden in vitro bei Viren an infizierten Zellen durchgef\u00fchrt. Diejenigen, die Aktivit\u00e4t zeigen, werden dann an Tiermodellen getestet. Bei Erfolg gehen wir zur klinischen Phase des Menschen \u00fcber, die normalerweise in drei Phasen unterteilt ist. Die erste dient bei einer kleinen Anzahl gesunder Menschen dazu, zu \u00fcberpr\u00fcfen, ob das potenzielle Medikament sicher ist und keine schwerwiegenden Nebenwirkungen hervorruft. Sie kann \u00fcbersprungen werden, wenn beispielsweise ein Molek\u00fcl verwendet wird, das bereits f\u00fcr andere Zwecke verwendet wird. Im zweiten Fall wird die Therapie an einer begrenzten Anzahl von Patienten getestet, um deren Wirksamkeit zu \u00fcberpr\u00fcfen. Wenn diese Phase ebenfalls bestanden wird, geht sie bei einer gr\u00f6\u00dferen Anzahl von Kranken auf die dritte \u00fcber.<\/p>\n

Quelle: https:\/\/www.iss.it<\/p>\n

\n

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\u0412 \u043d\u0430\u0441\u0442\u043e\u044f\u0449\u0435\u0435 \u0432\u0440\u0435\u043c\u044f \u043d\u0435 \u0441\u0443\u0449\u0435\u0441\u0442\u0432\u0443\u0435\u0442 \u043c\u0435\u0442\u043e\u0434\u043e\u0432 \u043b\u0435\u0447\u0435\u043d\u0438\u044f, \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u043e\u0432\u0430\u043d\u043d\u044b\u0445 \u0412\u0441\u0435\u043c\u0438\u0440\u043d\u043e\u0439 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u0430\u0446\u0438\u0435\u0439 \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044f (\u0412\u041e\u0417) \u0434\u043b\u044f \u043d\u043e\u0432\u043e\u0433\u043e \u043a\u043e\u0440\u043e\u043d\u0430\u0432\u0438\u0440\u0443\u0441\u0430, \u0438 \u0432 \u0440\u0443\u043a\u043e\u0432\u043e\u0434\u044f\u0449\u0438\u0445 \u0443\u043a\u0430\u0437\u0430\u043d\u0438\u044f\u0445 \u043f\u043e \u0443\u0445\u043e\u0434\u0443 \u0437\u0430 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430\u043c\u0438 \u0443\u043a\u0430\u0437\u0430\u043d\u044b \u0442\u043e\u043b\u044c\u043a\u043e \u043f\u043e\u0434\u0434\u0435\u0440\u0436\u0438\u0432\u0430\u044e\u0449\u0438\u0435 \u043c\u0435\u0442\u043e\u0434\u044b \u043b\u0435\u0447\u0435\u043d\u0438\u044f, \u0442\u0430\u043a\u0438\u0435 \u043a\u0430\u043a \u043a\u0438\u0441\u043b\u043e\u0440\u043e\u0434\u043d\u0430\u044f \u0442\u0435\u0440\u0430\u043f\u0438\u044f, \u0432\u0432\u0435\u0434\u0435\u043d\u0438\u0435 \u0436\u0438\u0434\u043a\u043e\u0441\u0442\u0438 \u0438 \u042d\u043c\u043f\u0438\u0440\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u0435 \u0430\u043d\u0442\u0438\u0431\u0438\u043e\u0442\u0438\u043a\u043e\u0432 \u0434\u043b\u044f \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u043b\u044e\u0431\u044b\u0445 \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u044b\u0445 \u0441\u043e\u043f\u0443\u0442\u0441\u0442\u0432\u0443\u044e\u0449\u0438\u0445 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0439. 11 \u0438 12 \u0444\u0435\u0432\u0440\u0430\u043b\u044f \u0412\u041e\u0417 \u0441\u043e\u0431\u0435\u0440\u0435\u0442 \u0444\u043e\u0440\u0443\u043c \u044d\u043a\u0441\u043f\u0435\u0440\u0442\u043e\u0432 \u0441\u043e \u0432\u0441\u0435\u0433\u043e \u043c\u0438\u0440\u0430, \u0447\u0442\u043e\u0431\u044b \u043e\u0431\u0441\u0443\u0434\u0438\u0442\u044c, \u043a\u0430\u043a \u0443\u0441\u043a\u043e\u0440\u0438\u0442\u044c \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u0432 \u043e\u0431\u043b\u0430\u0441\u0442\u0438 \u0432\u0430\u043a\u0446\u0438\u043d \u0438 \u0432\u043e\u0437\u043c\u043e\u0436\u043d\u044b\u0445 \u043c\u0435\u0442\u043e\u0434\u043e\u0432 \u043b\u0435\u0447\u0435\u043d\u0438\u044f. \u041e\u0434\u043d\u0430\u043a\u043e \u043d\u0435\u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u044b \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u044e\u0442 \u043d\u0435\u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430, \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u0443\u0436\u0435 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u044e\u0442\u0441\u044f \u0438\u043b\u0438 \u044d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442\u0438\u0440\u0443\u044e\u0442 \u0441 \u0434\u0440\u0443\u0433\u0438\u043c\u0438 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u043c\u0438, \u0432 \u0442\u043e \u0432\u0440\u0435\u043c\u044f \u043a\u0430\u043a \u0434\u043b\u044f \u0434\u0440\u0443\u0433\u0438\u0445 \u043d\u0430\u0447\u0430\u043b\u0438\u0441\u044c \u0434\u043e\u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0438\u0441\u043f\u044b\u0442\u0430\u043d\u0438\u044f \u0432\u0432\u0438\u0434\u0443 \u0432\u043e\u0437\u043c\u043e\u0436\u043d\u043e\u0433\u043e \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f, \u0432 \u043e\u0434\u043d\u043e\u043c \u0441\u043b\u0443\u0447\u0430\u0435 \u0442\u0430\u043a\u0436\u0435 \u0431\u043b\u0430\u0433\u043e\u0434\u0430\u0440\u044f \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f\u043c, \u043f\u0440\u043e\u0432\u0435\u0434\u0435\u043d\u043d\u044b\u043c \u0418\u043d\u0441\u0442\u0438\u0442\u0443\u0442\u043e\u043c.<\/p>\n

\u0420\u0435\u043c\u0434\u0435\u0441\u0438\u0432\u0438\u0440: \u044d\u0442\u043e\u0442 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442 \u0442\u0435\u0441\u0442\u0438\u0440\u0443\u0435\u0442\u0441\u044f \u043d\u0430 \u043b\u044e\u0434\u044f\u0445 \u043f\u0440\u043e\u0442\u0438\u0432 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0439 \u042d\u0431\u043e\u043b\u0430, \u0438 \u0442\u0435\u0441\u0442\u044b in vitro \u0442\u0430\u043a\u0436\u0435 \u043f\u043e\u043a\u0430\u0437\u0430\u043b\u0438 \u043d\u0435\u043a\u043e\u0442\u043e\u0440\u0443\u044e \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c \u043f\u0440\u043e\u0442\u0438\u0432 \u043a\u043e\u0440\u043e\u043d\u0430\u0432\u0438\u0440\u0443\u0441\u043e\u0432, \u0442\u0430\u043a\u0438\u0445 \u043a\u0430\u043a Sars \u0438 Mers. \u041e\u043d \u0431\u044b\u043b \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d \u043d\u0430 \u043f\u0435\u0440\u0432\u043e\u043c \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0435, \u0438\u043d\u0444\u0438\u0446\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u043c \u043d\u043e\u0432\u044b\u043c \u043a\u043e\u0440\u043e\u043d\u0430\u0432\u0438\u0440\u0443\u0441\u043e\u043c \u0432 \u0421\u043e\u0435\u0434\u0438\u043d\u0435\u043d\u043d\u044b\u0445 \u0428\u0442\u0430\u0442\u0430\u0445, \u043a\u0430\u043a \u043e\u043f\u0438\u0441\u0430\u043d\u043e \u0432 Lancet, \u0430 \u0432 \u043d\u0435\u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u043a\u0438\u0442\u0430\u0439\u0441\u043a\u0438\u0445 \u0431\u043e\u043b\u044c\u043d\u0438\u0446\u0430\u0445 \u044d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442 \u043f\u0440\u043e\u0432\u043e\u0434\u0438\u0442\u0441\u044f \u043f\u0440\u0438\u043c\u0435\u0440\u043d\u043e \u043d\u0430 800 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430\u0445.<\/p>\n

\u041b\u043e\u043f\u0438\u043d\u0430\u0432\u0438\u0440 \u0438 \u0440\u0438\u0442\u043e\u043d\u0430\u0432\u0438\u0440. \u041a\u043e\u043c\u0431\u0438\u043d\u0430\u0446\u0438\u044f \u044d\u0442\u0438\u0445 \u0434\u0432\u0443\u0445 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u0432 \u043f\u0440\u043e\u0442\u0438\u0432 \u0412\u0418\u0427 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043b\u0430\u0441\u044c \u0432 2004 \u0433\u043e\u0434\u0443 \u0432\u043e \u0432\u0440\u0435\u043c\u044f \u044d\u043f\u0438\u0434\u0435\u043c\u0438\u0438 \u0421\u0430\u0440\u0441 \u0438 \u0432 \u043d\u0430\u0441\u0442\u043e\u044f\u0449\u0435\u0435 \u0432\u0440\u0435\u043c\u044f \u0442\u0435\u0441\u0442\u0438\u0440\u0443\u0435\u0442\u0441\u044f \u043d\u0430 41 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0435 \u0432 \u0431\u043e\u043b\u044c\u043d\u0438\u0446\u0435 \u0432 \u0423\u0445\u0430\u043d\u0438 \u0432\u043c\u0435\u0441\u0442\u0435 \u0441 \u0434\u043e\u0437\u043e\u0439 \u0430\u043b\u044c\u0444\u0430-\u0438\u043d\u0442\u0435\u0440\u0444\u0435\u0440\u043e\u043d\u0430.<\/p>\n

\u0425\u043b\u043e\u0440\u043e\u0445\u0438\u043d: \u044d\u0442\u043e\u0442 \u043f\u0440\u043e\u0442\u0438\u0432\u043e\u043c\u0430\u043b\u044f\u0440\u0438\u0439\u043d\u044b\u0439 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u0435\u0442\u0441\u044f \u0443\u0436\u0435 \u0431\u043e\u043b\u0435\u0435 70 \u043b\u0435\u0442, \u0438 \u043d\u0435\u0434\u0430\u0432\u043d\u043e \u041a\u0438\u0442\u0430\u0439\u0441\u043a\u0430\u044f \u043d\u0430\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u0430\u044f \u043a\u043e\u043c\u0438\u0441\u0441\u0438\u044f \u043f\u043e \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044e \u0443\u043a\u0430\u0437\u0430\u043b\u0430 \u0435\u0433\u043e \u0441\u0440\u0435\u0434\u0438 \u0442\u0435\u0445, \u043a\u0442\u043e \u043e\u0431\u043b\u0430\u0434\u0430\u0435\u0442 \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c\u044e in vitro \u043f\u0440\u043e\u0442\u0438\u0432 \u043d\u043e\u0432\u043e\u0433\u043e \u043a\u043e\u0440\u043e\u043d\u0430\u0432\u0438\u0440\u0443\u0441\u0430, \u043f\u043e \u043a\u043e\u0442\u043e\u0440\u043e\u043c\u0443 \u0431\u0443\u0434\u0443\u0442 \u043f\u0440\u043e\u0434\u043e\u043b\u0436\u0435\u043d\u044b \u0438\u0441\u043f\u044b\u0442\u0430\u043d\u0438\u044f. \u0421\u0440\u0435\u0434\u0438 \u043f\u0435\u0440\u0432\u044b\u0445 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0439 \u0434\u043b\u044f \u043f\u0440\u043e\u0432\u0435\u0440\u043a\u0438 \u0435\u0433\u043e \u0430\u043d\u0442\u0438\u0440\u0435\u0442\u0440\u043e\u0432\u0438\u0440\u0443\u0441\u043d\u043e\u0439 \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438, \u0432 \u0441\u043b\u0443\u0447\u0430\u0435 \u0441 \u0412\u0418\u0427, \u043e\u0434\u043d\u043e \u0431\u044b\u043b\u043e \u043f\u0440\u043e\u0432\u0435\u0434\u0435\u043d\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u044f\u043c\u0438 \u0438\u0437 Istituto Superiore di Sanit\u00e0, \u043a\u043e\u043e\u0440\u0434\u0438\u043d\u0438\u0440\u0443\u0435\u043c\u044b\u043c \u0434\u043e\u043a\u0442\u043e\u0440\u043e\u043c. \u0410\u043d\u0434\u0440\u0435\u0430 \u0421\u0430\u0432\u0430\u0440\u0438\u043d\u043e.<\/p>\n

\u0423\u043c\u0438\u0444\u0435\u043d\u043e\u0432\u0438\u0440 \u0438 \u0414\u0430\u0440\u0443\u043d\u0430\u0432\u0438\u0440: \u043f\u0435\u0440\u0432\u044b\u0439 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442 \u043f\u0440\u043e\u0442\u0438\u0432 \u0433\u0440\u0438\u043f\u043f\u0430, \u0430 \u0432\u0442\u043e\u0440\u043e\u0439 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442 \u043f\u0440\u043e\u0442\u0438\u0432 \u0412\u0418\u0427, \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u0435\u0442\u0441\u044f \u0443\u0436\u0435 \u043d\u0435\u0441\u043a\u043e\u043b\u044c\u043a\u043e \u043b\u0435\u0442. \u041e\u0431\u0430 \u043f\u043e\u043a\u0430\u0437\u0430\u043b\u0438 \u0431\u044b \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c \u043f\u0440\u043e\u0442\u0438\u0432 \u0432\u0438\u0440\u0443\u0441\u0430 in vitro.<\/p>\n

\u0424\u0430\u0437\u044b \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0438\u0441\u043f\u044b\u0442\u0430\u043d\u0438\u044f<\/strong><\/p>\n

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\u0418\u0441\u0442\u043e\u0447\u043d\u0438\u043a: https:\/\/www.iss.it<\/p>\n

\n

\u51a0\u72b6\u75c5\u6bd2\uff0c\u5173\u4e8e\u5b9e\u9a8c\u836f\u7269\u7684\u89c2\u70b9<\/strong><\/p>\n

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Remdesivir\uff1a\u8be5\u836f\u7269\u6b63\u5728\u9488\u5bf9\u4eba\u7c7b\u8fdb\u884c\u6297\u57c3\u535a\u62c9\u75c5\u6bd2\u611f\u67d3\u7684\u6d4b\u8bd5\uff0c\u5e76\u4e14\u5728\u4f53\u5916\u6d4b\u8bd5\u4e2d\uff0c\u5b83\u8fd8\u663e\u793a\u51fa\u6297\u51a0\u72b6\u75c5\u6bd2\uff08\u4f8b\u5982Sars\u548cMers\uff09\u7684\u67d0\u4e9b\u6d3b\u6027\u3002\u5982\u300a\u67f3\u53f6\u5200\u300b\u6742\u5fd7\u6240\u8ff0\uff0c\u5b83\u5df2\u5728\u7f8e\u56fd\u9996\u4f8b\u88ab\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\u7684\u60a3\u8005\u4e2d\u4f7f\u7528\uff0c\u5e76\u4e14\u5728\u4e2d\u56fd\u7684\u4e00\u4e9b\u533b\u9662\u4e2d\uff0c\u6b63\u5728\u8fdb\u884c\u9488\u5bf9\u7ea6800\u540d\u60a3\u8005\u7684\u5b9e\u9a8c\u3002<\/p>\n

Lopinavir\u548cRitonavir\uff1a\u8fd9\u4e24\u79cd\u6297HIV\u836f\u7269\u7684\u7ec4\u5408\u57282004\u5e74Sars\u6d41\u884c\u671f\u95f4\u4f7f\u7528\uff0c\u76ee\u524d\u6b63\u5728\u6b66\u6c49\u4e00\u5bb6\u533b\u9662\u768441\u4f8b\u60a3\u8005\u4e2d\u8fdb\u884c\u68c0\u6d4b\uff0c\u5e76\u914d\u5408\u4e86\u4e00\u5b9a\u5242\u91cf\u7684\u03b1\u5e72\u6270\u7d20\u3002<\/p>\n

\u6c2f\u55b9\uff1a\u8fd9\u79cd\u6297\u759f\u836f\u5df2\u7ecf\u4f7f\u7528\u4e8670\u591a\u5e74\uff0c\u6700\u8fd1\uff0c\u4e2d\u56fd\u56fd\u5bb6\u536b\u751f\u59d4\u5458\u4f1a\u5df2\u7ecf\u8868\u660e\u5b83\u5bf9\u65b0\u7684\u51a0\u72b6\u75c5\u6bd2\u5177\u6709\u4f53\u5916\u6d3b\u6027\uff0c\u5e76\u5c06\u7ee7\u7eed\u5bf9\u5176\u8fdb\u884c\u6d4b\u8bd5\u3002\u5728\u6700\u521d\u7684\u9a8c\u8bc1\u5176\u6297\u9006\u8f6c\u5f55\u75c5\u6bd2\u6d3b\u6027\u7684\u7814\u7a76\u4e2d\uff0c\u5728\u9488\u5bf9HIV\u7684\u7814\u7a76\u4e2d\uff0c\u7531Sanit\u00e0\u7684Istituto Superiore diSanit\u00e0\u7684\u7814\u7a76\u4eba\u5458\u8fdb\u884c\u4e86\u4e00\u9879\u7814\u7a76\u3002\u5b89\u5fb7\u91cc\u4e9a\u00b7\u8428\u74e6\u91cc\u8bfa\uff08Andrea Savarino\uff09\u3002<\/p>\n

Umifenovir\u548cDarunavir\uff1a\u524d\u8005\u662f\u4e00\u79cd\u6297\u6d41\u611f\u836f\u7269\uff0c\u800c\u540e\u8005\u662f\u4e00\u79cd\u5df2\u7ecf\u4f7f\u7528\u4e86\u51e0\u5e74\u7684\u6297HIV\u836f\u7269\u3002\u4e24\u8005\u90fd\u5c06\u5728\u4f53\u5916\u663e\u793a\u51fa\u5bf9\u75c5\u6bd2\u7684\u6d3b\u6027\u3002<\/p>\n

\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5404\u4e2a\u9636\u6bb5<\/strong><\/p>\n

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\u8d44\u6599\u6765\u6e90\uff1ahttps:\/\/www.iss.it<\/p>\n

\n

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\u0627\u0644\u0645\u0635\u062f\u0631: https:\/\/www.iss.it<\/p>\n

\n

Coronavirus \u060c \u0646\u06a9\u062a\u0647 \u0627\u06cc \u062f\u0631 \u0645\u0648\u0631\u062f \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u062a\u062c\u0631\u0628\u06cc<\/p>\n

\u062f\u0631 \u062d\u0627\u0644 \u062d\u0627\u0636\u0631 \u0647\u06cc\u0686 \u062f\u0631\u0645\u0627\u0646\u06cc \u062a\u0648\u0635\u06cc\u0647 \u0646\u0645\u06cc \u0634\u0648\u062f \u06a9\u0647 \u062a\u0648\u0633\u0637 \u0633\u0627\u0632\u0645\u0627\u0646 \u0628\u0647\u062f\u0627\u0634\u062a \u062c\u0647\u0627\u0646\u06cc (WHO) \u0628\u0631\u0627\u06cc \u06a9\u0631\u0648\u0646\u0627\u0648\u06cc\u0631\u0648\u0633 \u062c\u062f\u06cc\u062f \u0627\u0646\u062c\u0627\u0645 \u0634\u0648\u062f \u060c \u0648 \u062a\u0646\u0647\u0627 \u062f\u0631\u0645\u0627\u0646 \u0647\u0627\u06cc \u062d\u0645\u0627\u06cc\u062a\u06cc \u062f\u0631 \u062f\u0633\u062a\u0648\u0631\u0627\u0644\u0639\u0645\u0644 \u0647\u0627\u06cc \u0645\u0631\u0627\u0642\u0628\u062a \u0627\u0632 \u0628\u06cc\u0645\u0627\u0631 \u0645\u0627\u0646\u0646\u062f \u0627\u06a9\u0633\u06cc\u0698\u0646 \u062f\u0631\u0645\u0627\u0646\u06cc \u060c \u062a\u062c\u0648\u06cc\u0632 \u0645\u0627\u06cc\u0639\u0627\u062a \u0648 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u062a\u062c\u0631\u0628\u06cc \u0627\u0632 \u0622\u0646\u062a\u06cc \u0628\u06cc\u0648\u062a\u06cc\u06a9 \u0647\u0627 \u0628\u0631\u0627\u06cc \u062f\u0631\u0645\u0627\u0646 \u0647\u0631\u06af\u0648\u0646\u0647 \u0639\u0641\u0648\u0646\u062a \u0645\u0634\u062a\u0631\u06a9 \u0628\u0627\u06a9\u062a\u0631\u06cc\u0627\u06cc\u06cc. WHO \u062f\u0631 \u062a\u0627\u0631\u06cc\u062e 11 \u0648 12 \u0641\u0648\u0631\u06cc\u0647 \u0645\u062c\u0645\u0639 \u0645\u062a\u062e\u0635\u0635\u0627\u0646 \u0627\u0632 \u0633\u0631\u0627\u0633\u0631 \u062c\u0647\u0627\u0646 \u0631\u0627 \u0628\u0631\u0627\u06cc \u0628\u062d\u062b \u062f\u0631 \u0645\u0648\u0631\u062f \u0686\u06af\u0648\u0646\u06af\u06cc \u062a\u0633\u0631\u06cc\u0639 \u062a\u062d\u0642\u06cc\u0642\u0627\u062a \u062f\u0631 \u0645\u0648\u0631\u062f \u0648\u0627\u06a9\u0633\u0646 \u0647\u0627 \u0648 \u0631\u0648\u0634 \u0647\u0627\u06cc \u062f\u0631\u0645\u0627\u0646\u06cc \u0627\u062d\u062a\u0645\u0627\u0644\u06cc \u062c\u0645\u0639 \u0645\u06cc \u06a9\u0646\u062f. \u0628\u0627 \u0627\u06cc\u0646 \u062d\u0627\u0644 \u060c \u0628\u0631\u062e\u06cc \u0627\u0632 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u062f\u0631 \u062d\u0627\u0644 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u0628\u0631\u062e\u06cc \u062f\u0627\u0631\u0648\u0647\u0627\u06cc\u06cc \u0647\u0633\u062a\u0646\u062f \u06a9\u0647 \u0642\u0628\u0644\u0627\u064b \u062f\u0631 \u062d\u0627\u0644 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0647\u0633\u062a\u0646\u062f \u0648 \u06cc\u0627 \u062f\u0631 \u062d\u0627\u0644 \u0622\u0632\u0645\u0627\u06cc\u0634 \u0633\u0627\u06cc\u0631 \u0628\u06cc\u0645\u0627\u0631\u06cc\u0647\u0627 \u0647\u0633\u062a\u0646\u062f \u060c \u062f\u0631 \u062d\u0627\u0644\u06cc \u06a9\u0647 \u0628\u0631\u0627\u06cc \u0628\u0631\u062e\u06cc \u062f\u06cc\u06af\u0631 \u060c \u0622\u0632\u0645\u0627\u06cc\u0634\u0627\u062a \u0628\u0627\u0644\u06cc\u0646\u06cc \u0628\u0627 \u062a\u0648\u062c\u0647 \u0628\u0647 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u062d\u062a\u0645\u0627\u0644\u06cc \u0634\u0631\u0648\u0639 \u0634\u062f\u0647 \u0627\u0633\u062a \u060c \u062f\u0631 \u06cc\u06a9 \u0645\u0648\u0631\u062f \u0646\u06cc\u0632 \u0628\u0647 \u0644\u0637\u0641 \u0645\u0637\u0627\u0644\u0639\u0627\u062a \u0627\u0646\u062c\u0627\u0645 \u0634\u062f\u0647 \u062a\u0648\u0633\u0637 \u0627\u06cc\u0646 \u0645\u0648\u0633\u0633\u0647.<\/p>\n

Remdesivir: \u0627\u06cc\u0646 \u062f\u0627\u0631\u0648 \u0628\u0631 \u0631\u0648\u06cc \u0627\u0646\u0633\u0627\u0646 \u062f\u0631 \u0628\u0631\u0627\u0628\u0631 \u0639\u0641\u0648\u0646\u062a \u0627\u0628\u0648\u0644\u0627 \u0622\u0632\u0645\u0627\u06cc\u0634 \u0645\u06cc \u0634\u0648\u062f \u060c \u0648 \u062f\u0631 \u0622\u0632\u0645\u0627\u06cc\u0634\u0627\u062a \u0622\u0632\u0645\u0627\u06cc\u0634\u06af\u0627\u0647\u06cc \u0646\u06cc\u0632 \u0641\u0639\u0627\u0644\u06cc\u062a\u06cc \u0631\u0627 \u062f\u0631 \u0628\u0631\u0627\u0628\u0631 coronaviruses \u0645\u0627\u0646\u0646\u062f \u0633\u0627\u0631\u0633 \u0648 \u0645\u0631\u0633 \u0646\u0634\u0627\u0646 \u062f\u0627\u062f\u0647 \u0627\u0633\u062a. \u0647\u0645\u0627\u0646\u0637\u0648\u0631 \u06a9\u0647 \u062f\u0631 Lancet \u0634\u0631\u062d \u062f\u0627\u062f\u0647 \u0634\u062f\u0647 \u0627\u0633\u062a \u060c \u0628\u0631 \u0631\u0648\u06cc \u0627\u0648\u0644\u06cc\u0646 \u0628\u06cc\u0645\u0627\u0631 \u0622\u0644\u0648\u062f\u0647 \u0628\u0647 koronavirus \u062c\u062f\u06cc\u062f \u062f\u0631 \u0627\u06cc\u0627\u0644\u0627\u062a \u0645\u062a\u062d\u062f\u0647 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0634\u062f\u0647 \u0627\u0633\u062a \u060c \u0648 \u062f\u0631 \u0628\u0639\u0636\u06cc \u0627\u0632 \u0628\u06cc\u0645\u0627\u0631\u0633\u062a\u0627\u0646 \u0647\u0627\u06cc \u0686\u06cc\u0646 \u0622\u0632\u0645\u0627\u06cc\u0634 \u062f\u0631 \u0645\u0648\u0631\u062f 800 \u0628\u06cc\u0645\u0627\u0631 \u0627\u0646\u062c\u0627\u0645 \u0645\u06cc \u0634\u0648\u062f.<\/p>\n

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Umifenovir \u0648 Darunavir: \u0627\u0648\u0644\u06cc \u06cc\u06a9 \u062f\u0627\u0631\u0648\u06cc \u0636\u062f \u0622\u0646\u0641\u0648\u0644\u0627\u0646\u0632\u0627 \u0627\u0633\u062a \u060c \u062f\u0631 \u062d\u0627\u0644\u06cc \u06a9\u0647 \u062f\u0648\u0645\u06cc \u06cc\u06a9 \u062f\u0627\u0631\u0648\u06cc \u0636\u062f HIV \u0627\u0633\u062a \u06a9\u0647 \u0686\u0646\u062f\u06cc\u0646 \u0633\u0627\u0644 \u0627\u0633\u062a \u06a9\u0647 \u062f\u0631 \u062d\u0627\u0644 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0633\u062a. \u0647\u0631 \u062f\u0648 \u0641\u0639\u0627\u0644\u06cc\u062a \u0639\u0644\u06cc\u0647 \u0648\u06cc\u0631\u0648\u0633 \u062f\u0631 \u0634\u0631\u0627\u06cc\u0637 \u0622\u0632\u0645\u0627\u06cc\u0634\u06af\u0627\u0647\u06cc \u0646\u0634\u0627\u0646 \u0645\u06cc \u062f\u0627\u062f\u0646\u062f.<\/p>\n

\u0645\u0631\u0627\u062d\u0644 \u06cc\u06a9 \u06a9\u0627\u0631\u0622\u0632\u0645\u0627\u06cc\u06cc \u0628\u0627\u0644\u06cc\u0646\u06cc<\/p>\n

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\u0645\u0646\u0628\u0639: https:\/\/www.iss.it<\/p>\n

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Coronavirus, deneysel ila\u00e7lar\u0131n noktas\u0131<\/strong><\/p>\n

\u015eu anda D\u00fcnya Sa\u011fl\u0131k \u00d6rg\u00fct\u00fc (WHO) taraf\u0131ndan yeni koronavir\u00fcs i\u00e7in \u00f6nerilen tedaviler yoktur ve hasta tedavisi k\u0131lavuzlar\u0131nda oksijen terapisi, s\u0131v\u0131 uygulamas\u0131 ve bakteriyel koenfeksiyonlar\u0131 tedavi etmek i\u00e7in ampirik antibiyotik kullan\u0131m\u0131. DS\u00d6, a\u015f\u0131lar ve olas\u0131 tedavilerle ilgili ara\u015ft\u0131rmalar\u0131 nas\u0131l h\u0131zland\u0131raca\u011f\u0131n\u0131 tart\u0131\u015fmak i\u00e7in 11 ve 12 \u015eubat’ta d\u00fcnyan\u0131n d\u00f6rt bir yan\u0131ndan uzmanlardan olu\u015fan bir forum toplayacak. Bununla birlikte, baz\u0131 hastalar halihaz\u0131rda kullan\u0131mda olan veya di\u011fer hastal\u0131klar\u0131 deneyen baz\u0131 ila\u00e7lar\u0131 kullan\u0131rken, di\u011ferleri i\u00e7in, bir durumda Enstit\u00fc taraf\u0131ndan y\u00fcr\u00fct\u00fclen \u00e7al\u0131\u015fmalar sayesinde olas\u0131 bir kullan\u0131m a\u00e7\u0131s\u0131ndan preklinik testler ba\u015flam\u0131\u015ft\u0131r.<\/p>\n

Remdesivir: Bu ila\u00e7 insanlar \u00fczerinde Ebola enfeksiyonlar\u0131na kar\u015f\u0131 test ediliyor ve in vitro testler de Sars ve Mers gibi koronavir\u00fcslere kar\u015f\u0131 baz\u0131 aktiviteler g\u00f6sterdi. Lancet’te a\u00e7\u0131kland\u0131\u011f\u0131 gibi, ABD’de yeni koronavir\u00fcs ile enfekte olan ilk hastada kullan\u0131lm\u0131\u015ft\u0131r ve baz\u0131 \u00c7in hastanelerinde yakla\u015f\u0131k 800 hasta \u00fczerinde bir deney devam etmektedir.<\/p>\n

Lopinavir ve Ritonavir: Bu iki anti-HIV ilac\u0131n\u0131n kombinasyonu Sars salg\u0131n\u0131 s\u0131ras\u0131nda 2004 y\u0131l\u0131nda kullan\u0131ld\u0131 ve Wuhan’daki bir hastanede bulunan 41 hasta \u00fczerinde alfa interferon dozu ile test ediliyor.<\/p>\n

Klorokin: Bu antimalaryal ila\u00e7 70 y\u0131l\u0131 a\u015fk\u0131n bir s\u00fcredir kullan\u0131lmaktad\u0131r ve son zamanlarda \u00c7in Ulusal Sa\u011fl\u0131k Komisyonu, testlerin devam edece\u011fi yeni koronavir\u00fcse kar\u015f\u0131 in vitro aktiviteye sahip olanlar aras\u0131nda bunu g\u00f6stermi\u015ftir. Antiretroviral aktivitesini do\u011frulamak i\u00e7in yap\u0131lan ilk \u00e7al\u0131\u015fmalar aras\u0131nda, HIV’e kar\u015f\u0131 olan vakada, dr taraf\u0131ndan koordine edilen Istituto Superiore di Sanit\u00e0’dan ara\u015ft\u0131rmac\u0131lar taraf\u0131ndan y\u00fcr\u00fct\u00fclm\u00fc\u015ft\u00fcr. Andrea Savarino.<\/p>\n

Umifenovir ve Darunavir: Birincisi bir anti-grip ilac\u0131, ikincisi birka\u00e7 y\u0131ld\u0131r kullan\u0131lan bir anti-HIV ilac\u0131d\u0131r. Her ikisi de in vitro vir\u00fcse kar\u015f\u0131 aktivite g\u00f6sterirdi.<\/p>\n

Klinik ara\u015ft\u0131rman\u0131n a\u015famalar\u0131<\/strong><\/p>\n

Onaylanmadan \u00f6nce, bir ila\u00e7 hem klinik \u00f6ncesi hem de klinik \u00e7e\u015fitli deney a\u015famalar\u0131ndan ge\u00e7er. \u0130lk testler, enfekte olmu\u015f h\u00fccreler \u00fczerindeki vir\u00fcsler durumunda in vitro ger\u00e7ekle\u015ftirilir. Aktivite g\u00f6sterenler daha sonra hayvan modelleri \u00fczerinde test edilir. Ba\u015far\u0131l\u0131 olursa, genellikle \u00fc\u00e7 a\u015famaya b\u00f6l\u00fcnen insan klinik faz\u0131na ge\u00e7eriz. Birincisi, az say\u0131da sa\u011fl\u0131kl\u0131 insanda, potansiyel ilac\u0131n g\u00fcvenli oldu\u011funu ve ciddi yan etkiler vermedi\u011fini do\u011frulamaya hizmet eder ve \u00f6rne\u011fin, ba\u015fka ama\u00e7lar i\u00e7in kullan\u0131lmakta olan bir molek\u00fcl kullan\u0131l\u0131yorsa atlanabilir. \u0130kincisinde, s\u0131n\u0131rl\u0131 say\u0131da hastada tedavi, etkinliklerini do\u011frulamak i\u00e7in test edilir. Bu a\u015fama da ge\u00e7ilirse, daha fazla say\u0131da hasta insanda \u00fc\u00e7\u00fcnc\u00fcye ge\u00e7er.<\/p>\n

Kaynak: https:\/\/www.iss.it<\/p>\n

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\u5b9f\u9a13\u85ac\u306e\u30dd\u30a4\u30f3\u30c8\u3067\u3042\u308b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9<\/strong><\/p>\n

\u73fe\u5728\u3001\u65b0\u3057\u3044\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3057\u3066\u4e16\u754c\u4fdd\u5065\u6a5f\u95a2\uff08WHO\uff09\u304c\u63a8\u5968\u3059\u308b\u6cbb\u7642\u6cd5\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u307e\u305f\u3001\u9178\u7d20\u7642\u6cd5\u3001\u8f38\u6db2\u6295\u4e0e\u306a\u3069\u306e\u652f\u6301\u7642\u6cd5\u306e\u307f\u304c\u60a3\u8005\u30b1\u30a2\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6297\u751f\u7269\u8cea\u306e\u7d4c\u9a13\u7684\u4f7f\u7528\u306b\u3088\u308b\u7d30\u83cc\u306e\u91cd\u611f\u67d3\u306e\u6cbb\u7642\u3002 WHO\u306f2\u670811\u65e5\u306812\u65e5\u306b\u4e16\u754c\u4e2d\u304b\u3089\u5c02\u9580\u5bb6\u306e\u30d5\u30a9\u30fc\u30e9\u30e0\u3092\u96c6\u3081\u3001\u30ef\u30af\u30c1\u30f3\u3068\u53ef\u80fd\u306a\u7642\u6cd5\u306e\u7814\u7a76\u3092\u52a0\u901f\u3059\u308b\u65b9\u6cd5\u306b\u3064\u3044\u3066\u8b70\u8ad6\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u4e00\u90e8\u306e\u60a3\u8005\u306f\u3059\u3067\u306b\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u3044\u304f\u3064\u304b\u306e\u85ac\u7269\u3092\u4f7f\u7528\u3057\u3066\u3044\u308b\u3001\u307e\u305f\u306f\u4ed6\u306e\u75c5\u72b6\u3092\u5b9f\u9a13\u3057\u3066\u3044\u308b\u4e00\u65b9\u3067\u3001\u4ed6\u306e\u60a3\u8005\u3067\u306f\u53ef\u80fd\u6027\u306e\u3042\u308b\u4f7f\u7528\u3092\u8003\u616e\u3057\u3066\u524d\u81e8\u5e8a\u8a66\u9a13\u304c\u958b\u59cb\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u30ec\u30e0\u30c7\u30b7\u30d3\u30eb\uff1a\u3053\u306e\u85ac\u306f\u30a8\u30dc\u30e9\u611f\u67d3\u75c7\u306b\u5bfe\u3057\u3066\u30d2\u30c8\u3067\u30c6\u30b9\u30c8\u3055\u308c\u3066\u304a\u308a\u3001in vitro\u30c6\u30b9\u30c8\u3067\u306fSars\u3084Mers\u306a\u3069\u306e\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3057\u3066\u3082\u3042\u308b\u7a0b\u5ea6\u306e\u6d3b\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002 Lancet\u306b\u8a18\u8f09\u3055\u308c\u3066\u3044\u308b\u3088\u3046\u306b\u3001\u7c73\u56fd\u3067\u65b0\u3057\u3044\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306b\u611f\u67d3\u3057\u305f\u6700\u521d\u306e\u60a3\u8005\u306b\u4f7f\u7528\u3055\u308c\u3066\u304a\u308a\u3001\u4e00\u90e8\u306e\u4e2d\u56fd\u306e\u75c5\u9662\u3067\u306f\u7d04800\u4eba\u306e\u60a3\u8005\u3067\u8a66\u9a13\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u30ed\u30d4\u30ca\u30d3\u30eb\u3068\u30ea\u30c8\u30ca\u30d3\u30eb\uff1a\u3053\u308c\u30892\u3064\u306e\u6297HIV\u85ac\u306e\u7d44\u307f\u5408\u308f\u305b\u306f\u30012004\u5e74\u306bSars\u306e\u6d41\u884c\u306e\u969b\u306b\u4f7f\u7528\u3055\u308c\u3001\u6b66\u6f22\u306e\u75c5\u9662\u306741\u4eba\u306e\u60a3\u8005\u3068\u30a2\u30eb\u30d5\u30a1\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u306e\u7528\u91cf\u3067\u30c6\u30b9\u30c8\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u30af\u30ed\u30ed\u30ad\u30f3\uff1a\u3053\u306e\u6297\u30de\u30e9\u30ea\u30a2\u85ac\u306f70\u5e74\u4ee5\u4e0a\u4f7f\u7528\u3055\u308c\u3066\u304a\u308a\u3001\u6700\u8fd1\u3001\u4e2d\u56fd\u56fd\u5bb6\u885b\u751f\u59d4\u54e1\u4f1a\u306f\u3001\u8a66\u9a13\u304c\u7d99\u7d9a\u3055\u308c\u308b\u65b0\u3057\u3044\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3057\u3066in vitro\u3067\u306e\u6d3b\u6027\u3092\u6709\u3059\u308b\u4eba\u3005\u306e\u9593\u3067\u305d\u308c\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u6297\u30ec\u30c8\u30ed\u30a6\u30a4\u30eb\u30b9\u6d3b\u6027\u3092\u691c\u8a3c\u3059\u308b\u6700\u521d\u306e\u7814\u7a76\u306e\u4e2d\u3067\u3001HIV\u306e\u5834\u5408\u3001\u535a\u58eb\u306b\u3088\u3063\u3066\u8abf\u6574\u3055\u308c\u305f\u30a4\u30b9\u30c6\u30a3\u30c8\u30a5\u30fc\u30c8\u30b9\u30da\u30ea\u30aa\u30fc\u30ec\u30c7\u30a3\u30b5\u30cb\u30bf\u306e\u7814\u7a76\u8005\u306b\u3088\u3063\u3066\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u30a2\u30f3\u30c9\u30ec\u30a2\u30fb\u30b5\u30d0\u30ea\u30ce\u3002<\/p>\n

\u30a6\u30df\u30d5\u30a7\u30ce\u30d3\u30eb\u3068\u30c0\u30eb\u30ca\u30d3\u30eb\uff1a\u524d\u8005\u306f\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30ef\u30af\u30c1\u30f3\u3067\u3042\u308a\u3001\u5f8c\u8005\u306f\u6570\u5e74\u524d\u304b\u3089\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u6297HIV\u85ac\u3067\u3059\u3002\u4e21\u65b9\u3068\u3082in vitro\u3067\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3059\u308b\u6d3b\u6027\u3092\u793a\u3057\u305f\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u81e8\u5e8a\u8a66\u9a13\u306e\u6bb5\u968e<\/strong><\/p>\n

\u627f\u8a8d\u3055\u308c\u308b\u524d\u306b\u3001\u85ac\u7269\u306f\u524d\u81e8\u5e8a\u3068\u81e8\u5e8a\u306e\u4e21\u65b9\u306e\u3044\u304f\u3064\u304b\u306e\u5b9f\u9a13\u6bb5\u968e\u3092\u7d4c\u307e\u3059\u3002\u6700\u521d\u306e\u30c6\u30b9\u30c8\u306f\u3001\u611f\u67d3\u7d30\u80de\u4e0a\u306e\u30a6\u30a4\u30eb\u30b9\u306e\u5834\u5408\u3001in vitro\u3067\u5b9f\u884c\u3055\u308c\u307e\u3059\u3002\u6d3b\u52d5\u3092\u793a\u3059\u3082\u306e\u306f\u3001\u52d5\u7269\u30e2\u30c7\u30eb\u3067\u30c6\u30b9\u30c8\u3055\u308c\u307e\u3059\u3002\u6210\u529f\u3057\u305f\u5834\u5408\u3001\u4eba\u9593\u306e\u81e8\u5e8a\u6bb5\u968e\u306b\u9032\u307f\u307e\u3059\u3002\u3053\u308c\u306f\u901a\u5e38\u30013\u3064\u306e\u6bb5\u968e\u306b\u5206\u3051\u3089\u308c\u307e\u3059\u3002\u6700\u521d\u306e\u5c11\u6570\u306e\u5065\u5eb7\u306a\u4eba\u3067\u306f\u3001\u6f5c\u5728\u7684\u306a\u85ac\u304c\u5b89\u5168\u3067\u3042\u308a\u3001\u6df1\u523b\u306a\u526f\u4f5c\u7528\u3092\u4e0e\u3048\u306a\u3044\u3053\u3068\u3092\u691c\u8a3c\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u3001\u4f8b\u3048\u3070\u3001\u3059\u3067\u306b\u4ed6\u306e\u76ee\u7684\u3067\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u5206\u5b50\u304c\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u5834\u5408\u306f\u30b9\u30ad\u30c3\u30d7\u3067\u304d\u307e\u3059\u3002\u7b2c\u4e8c\u306b\u3001\u6cbb\u7642\u306f\u9650\u3089\u308c\u305f\u6570\u306e\u60a3\u8005\u3067\u30c6\u30b9\u30c8\u3055\u308c\u3001\u5f7c\u3089\u306e\u6709\u52b9\u6027\u3092\u691c\u8a3c\u3057\u307e\u3059\u3002\u3053\u306e\u30d5\u30a7\u30fc\u30ba\u3082\u5408\u683c\u3059\u308b\u3068\u3001\u3088\u308a\u591a\u304f\u306e\u75c5\u6c17\u306e\u4eba\u306e3\u756a\u76ee\u306e\u30d5\u30a7\u30fc\u30ba\u306b\u79fb\u884c\u3057\u307e\u3059\u3002<\/p>\n

\u30bd\u30fc\u30b9\uff1ahttps:\/\/www.iss.it<\/p>\n

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\uc2e4\ud5d8 \uc57d\ubb3c\uc5d0 \ub300\ud55c \uc694\uc810 \ucf54\ub85c\ub098 \ubc14\uc774\ub7ec\uc2a4<\/strong><\/p>\n

\ud604\uc7ac \uc0c8\ub85c\uc6b4 \ucf54\ub85c\ub098 \ubc14\uc774\ub7ec\uc2a4\uc5d0 \ub300\ud574 \uc138\uacc4 \ubcf4\uac74\uae30\uad6c (WHO)\uac00 \uad8c\uc7a5\ud558\ub294 \uc694\ubc95\uc740 \uc5c6\uc73c\uba70, \uc0b0\uc18c \uc694\ubc95, \uccb4\uc561 \ud22c\uc5ec \ubc0f \ubc15\ud14c\ub9ac\uc544\uc758 \uacf5\ub3d9 \uac10\uc5fc\uc744 \uce58\ub8cc\ud558\uae30 \uc704\ud574 \ud56d\uc0dd\uc81c\uc758 \uc2e4\ud5d8\uc801 \uc0ac\uc6a9. WHO\ub294 2 \uc6d4 11 \uc77c\uacfc 12 \uc77c\uc5d0 \uc804 \uc138\uacc4 \uc804\ubb38\uac00 \ud3ec\ub7fc\uc744 \ubaa8\uc544 \ubc31\uc2e0 \ubc0f \uac00\ub2a5\ud55c \uce58\ub8cc\ubc95\uc5d0 \ub300\ud55c \uc5f0\uad6c \uc18d\ub3c4\ub97c \ub192\uc774\ub294 \ubc29\ubc95\uc5d0 \ub300\ud574 \ub17c\uc758\ud569\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc77c\ubd80 \ud658\uc790\ub294 \uc774\ubbf8 \uc0ac\uc6a9 \uc911\uc774\uac70\ub098 \ub2e4\ub978 \uc9c8\ubcd1\uc5d0 \ub300\ud55c \uc2e4\ud5d8\uc744\ud558\ub294 \uc77c\ubd80 \uc57d\ubb3c\uc744 \uc0ac\uc6a9\ud558\uace0\uc788\ub294 \ubc18\uba74, \ub2e4\ub978 \uacbd\uc6b0\uc5d0\ub294 \uac00\ub2a5\ud55c \ud55c \uc0ac\uc6a9\uc744 \uace0\ub824\ud558\uc5ec \uc804\uc784\uc0c1 \ud14c\uc2a4\ud2b8\uac00 \uc2dc\uc791\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n

Remdesivir :\uc774 \uc57d\ubb3c\uc740 \uc5d0\ubcfc\ub77c \uac10\uc5fc\uc5d0 \ub300\ud574 \uc0ac\ub78c\uc5d0 \ub300\ud574 \ud14c\uc2a4\ud2b8\ub418\uace0 \uc788\uc73c\uba70 \uc2dc\ud5d8\uad00 \ub0b4 \ud14c\uc2a4\ud2b8\uc5d0\uc11c\ub294 Sars \ubc0f Mers\uc640 \uac19\uc740 \ucf54\ub85c\ub098 \ubc14\uc774\ub7ec\uc2a4\uc5d0 \ub300\ud55c \uc77c\ubd80 \ud65c\uc131\ub3c4 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4. Lancet\uc5d0 \uc124\uba85 \ub41c\ub300\ub85c \ubbf8\uad6d\uc5d0\uc11c \uc0c8\ub85c\uc6b4 \ucf54\ub85c\ub098 \ubc14\uc774\ub7ec\uc2a4\uc5d0 \uac10\uc5fc\ub41c \uccab \ubc88\uc9f8 \ud658\uc790\uc5d0\uac8c \uc0ac\uc6a9\ub418\uc5c8\uc73c\uba70 \uc77c\ubd80 \uc911\uad6d \ubcd1\uc6d0\uc5d0\uc11c\ub294 \uc57d 800 \uba85\uc758 \ud658\uc790\uc5d0 \ub300\ud55c \uc2e4\ud5d8\uc774 \uc9c4\ud589\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

Lopinavir\uc640 Ritonavir :\uc774 \ub450 \ud56d -HIV \uc57d\ubb3c\uc758 \uc870\ud569\uc740 2004 \ub144 Sars \uc804\uc5fc\ubcd1 \uae30\uac04 \ub3d9\uc548 \uc0ac\uc6a9\ub418\uc5c8\uc73c\uba70 \uc6b0\ud55c \ubcd1\uc6d0\uc758 41 \uba85\uc758 \ud658\uc790\uc640 \uc54c\ud30c \uc778\ud130\ud398\ub860\uc758 \ubcf5\uc6a9\ub7c9\uc5d0\uc11c \ud14c\uc2a4\ud2b8\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\ud074\ub85c\ub85c\ud038 :\uc774 \ub9d0\ub77c\ub9ac\uc544 \uc608\ubc29\uc57d\uc740 70 \ub144 \uc774\uc0c1 \uc0ac\uc6a9\ub418\uc5b4 \uc654\uc73c\uba70, \ucd5c\uadfc \uc911\uad6d \ubcf4\uac74\uc704\uc6d0\ud68c\ub294 \uc0c8\ub85c\uc6b4 \ucf54\ub85c\ub098 \ubc14\uc774\ub7ec\uc2a4\uc5d0 \ub300\ud574 \uc2dc\ud5d8\uad00 \ub0b4\uc5d0\uc11c \uc2dc\ud5d8\uad00 \ub0b4 \ud65c\ub3d9\uc744\ud558\ub294 \uc0ac\ub78c\ub4e4\uc5d0\uac8c\uc774 \uc57d\ubb3c\uc744 \ucc98\ubc29\ud588\uc2b5\ub2c8\ub2e4. \ud56d \ub808\ud2b8\ub85c \ubc14\uc774\ub7ec\uc2a4 \ud65c\uc131\uc744 \uac80\uc99d\ud558\uae30\uc704\ud55c \ucd5c\ucd08\uc758 \uc5f0\uad6c \uc911 HIV\uc5d0 \ub300\ud55c \uacbd\uc6b0, \ubc15\uc0ac\uc5d0 \uc758\ud574 \uc870\uc815 \ub41c Istituto Superiore di Sanit\u00e0\uc758 \uc5f0\uad6c\uc790\ub4e4\uc774 \uc218\ud589\ud588\uc2b5\ub2c8\ub2e4. \uc548\ub4dc\ub808\uc544 \uc0ac\ubc14 \ub9ac\ub178.<\/p>\n

Umifenovir \ubc0f Darunavir : \uc804\uc790\ub294 \ud56d \ub3c5\uac10 \uc57d\ubb3c\uc774\uace0 \ud6c4\uc790\ub294 \uc218\ub144\uac04 \uc0ac\uc6a9 \ub41c \ud56d HIV \uc57d\ubb3c\uc785\ub2c8\ub2e4. \ub458 \ub2e4 \uc2dc\ud5d8 \uad00\ub0b4 \ubc14\uc774\ub7ec\uc2a4\uc5d0 \ub300\ud55c \ud65c\uc131\uc744 \ub098\ud0c0 \ub0c8\uc744 \uac83\uc774\ub2e4.<\/p>\n

\uc784\uc0c1 \uc2dc\ud5d8\uc758 \ub2e8\uacc4<\/strong><\/p>\n

\uc2b9\uc778\ub418\uae30 \uc804\uc5d0 \uc57d\ubb3c\uc740 \uc804\uc784\uc0c1 \ubc0f \uc784\uc0c1\uc758 \uc5ec\ub7ec \ub2e8\uacc4\uc758 \uc2e4\ud5d8\uc744 \uac70\uce69\ub2c8\ub2e4. \uccab \ubc88\uc9f8 \ud14c\uc2a4\ud2b8\ub294 \uac10\uc5fc\ub41c \uc138\ud3ec\uc758 \ubc14\uc774\ub7ec\uc2a4\uc758 \uacbd\uc6b0 \uc2dc\ud5d8\uad00 \ub0b4\uc5d0\uc11c \uc218\ud589\ub429\ub2c8\ub2e4. \ud65c\ub3d9\uc744 \ubcf4\uc5ec\uc8fc\ub294 \uc0ac\ub78c\ub4e4\uc740 \ub3d9\ubb3c \ubaa8\ub378\uc5d0\uc11c \ud14c\uc2a4\ud2b8\ub429\ub2c8\ub2e4. \uc131\uacf5\ud558\uba74 \uc6b0\ub9ac\ub294 \uc778\uac04 \uc784\uc0c1 \ub2e8\uacc4\ub85c \ub118\uc5b4\uac00\ub294\ub370, \ubcf4\ud1b5 3 \ub2e8\uacc4\ub85c \ub098\ub269\ub2c8\ub2e4. \uccab \ubc88\uc9f8\ub294 \uc18c\uc218\uc758 \uac74\uac15\ud55c \uc0ac\ub78c\ub4e4\uc5d0\uac8c \uc7a0\uc7ac\uc801 \uc57d\ubb3c\uc774 \uc548\uc804\ud558\uace0 \uc2ec\uac01\ud55c \ubd80\uc791\uc6a9\uc744 \uc77c\uc73c\ud0a4\uc9c0 \uc54a\ub294\uc9c0 \ud655\uc778\ud558\ub294 \uc5ed\ud560\uc744\ud558\uba70, \uc608\ub97c \ub4e4\uc5b4 \ub2e4\ub978 \ubaa9\uc801\uc73c\ub85c \uc774\ubbf8 \uc0ac\uc6a9\uc911\uc778 \ubd84\uc790\ub97c \uc0ac\uc6a9\ud558\ub294 \uacbd\uc6b0 \uac74\ub108 \ub6f8 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub450 \ubc88\uc9f8\ub85c, \uce58\ub8cc\ub294 \ud6a8\uacfc\ub97c \ud655\uc778\ud558\uae30 \uc704\ud574 \uc81c\ud55c\ub41c \uc218\uc758 \ud658\uc790\uc5d0 \ub300\ud574 \ud14c\uc2a4\ud2b8\ub429\ub2c8\ub2e4. \uc774 \ub2e8\uacc4\ub3c4 \ud1b5\uacfc\ub418\uba74 \ub354 \ub9ce\uc740 \uc218\uc758 \uc544\ud508 \uc0ac\ub78c\ub4e4\uc5d0\uac8c \uc138 \ubc88\uc9f8 \ub2e8\uacc4\ub85c \ub118\uc5b4\uac11\ub2c8\ub2e4.<\/p>\n

\ucd9c\ucc98 : https:\/\/www.iss.it<\/p>\n

\n

Coronavirus, intinya tentang obat-obatan eksperimental<\/strong><\/p>\n

Saat ini tidak ada terapi yang direkomendasikan oleh Organisasi Kesehatan Dunia (WHO) untuk coronavirus baru, dan hanya terapi pendukung yang diindikasikan dalam pedoman perawatan pasien, seperti terapi oksigen, pemberian cairan dan penggunaan antibiotik secara empiris untuk mengobati koinfeksi bakteri apa pun. WHO akan mengumpulkan forum para ahli dari seluruh dunia pada 11 dan 12 Februari untuk membahas bagaimana mempercepat penelitian tentang vaksin dan kemungkinan terapi. Namun, beberapa pasien menggunakan beberapa obat yang sudah digunakan atau bereksperimen dengan penyakit lain, sementara untuk yang lain, tes praklinis telah dimulai mengingat kemungkinan penggunaannya, dalam satu kasus juga berkat penelitian yang dilakukan oleh Institute.<\/p>\n

Remdesivir: obat ini sedang diuji pada manusia terhadap infeksi Ebola, dan tes in vitro juga menunjukkan beberapa aktivitas melawan virus corona seperti Sars dan Mers. Ini telah digunakan pada pasien pertama yang terinfeksi coronavirus baru di Amerika Serikat, seperti yang dijelaskan dalam Lancet, dan percobaan sedang dilakukan pada sekitar 800 pasien di beberapa rumah sakit Cina.<\/p>\n

Lopinavir dan Ritonavir: kombinasi dari dua obat anti-HIV ini digunakan pada tahun 2004 selama epidemi Sars, dan sedang diuji pada 41 pasien di rumah sakit di Wuhan, bersama dengan dosis interferon alfa.<\/p>\n

Chloroquine: obat antimalaria ini telah digunakan selama lebih dari 70 tahun, dan baru-baru ini Komisi Kesehatan Nasional China telah mengindikasikannya di antara mereka yang memiliki aktivitas in vitro terhadap virus corona baru yang akan terus diuji. Di antara penelitian pertama yang memverifikasi aktivitas antiretroviralnya, dalam kasus melawan HIV, satu dilakukan oleh para peneliti dari Istituto Superiore di Sanit\u00e0 yang dikoordinasikan oleh dr. Andrea Savarino.<\/p>\n

Umifenovir dan Darunavir: yang pertama adalah obat anti-flu, sedangkan yang terakhir adalah obat anti-HIV yang telah digunakan selama beberapa tahun. Keduanya akan menunjukkan aktivitas melawan virus in vitro.<\/p>\n

Fase-fase uji klinis<\/strong><\/p>\n

Sebelum disetujui, suatu obat melewati beberapa fase percobaan, baik praklinis dan klinis. Tes pertama dilakukan secara in vitro, dalam hal virus pada sel yang terinfeksi. Kegiatan yang menunjukkan kemudian diuji pada model hewan. Jika berhasil, kami beralih ke fase klinis manusia, yang biasanya dibagi menjadi tiga fase. Yang pertama, pada sejumlah kecil orang sehat, berfungsi untuk memverifikasi bahwa obat potensial itu aman dan tidak memberikan efek samping yang serius, dan dapat dilewati jika, misalnya, molekul digunakan yang sudah digunakan untuk keperluan lain. Pada yang kedua, terapi diuji pada sejumlah pasien, untuk memverifikasi efektivitasnya. Jika fase ini juga dilewati, fase ini berlanjut ke tahap ketiga, pada jumlah orang sakit yang lebih banyak.<\/p>\n

Sumber: https:\/\/www.iss.it<\/p>\n

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\u0915\u094b\u0930\u094b\u0928\u093e\u0935\u093e\u092f\u0930\u0938, \u092a\u094d\u0930\u092f\u094b\u0917\u093e\u0924\u094d\u092e\u0915 \u0926\u0935\u093e\u0913\u0902 \u092a\u0930 \u092c\u093f\u0902\u0926\u0941<\/strong><\/p>\n

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\u0938\u094d\u0930\u094b\u0924: https:\/\/www.iss.it<\/p>\n

\n

Coronavirus, \u0111i\u1ec3m tr\u00ean thu\u1ed1c th\u1eed nghi\u1ec7m<\/strong><\/p>\n

Hi\u1ec7n t\u1ea1i kh\u00f4ng c\u00f3 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb n\u00e0o \u0111\u01b0\u1ee3c T\u1ed5 ch\u1ee9c Y t\u1ebf Th\u1ebf gi\u1edbi (WHO) khuy\u1ebfn c\u00e1o \u0111\u1ed1i v\u1edbi coronavirus m\u1edbi v\u00e0 ch\u1ec9 c\u00f3 c\u00e1c li\u1ec7u ph\u00e1p h\u1ed7 tr\u1ee3 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong h\u01b0\u1edbng d\u1eabn ch\u0103m s\u00f3c b\u1ec7nh nh\u00e2n, nh\u01b0 li\u1ec7u ph\u00e1p oxy, truy\u1ec1n d\u1ecbch v\u00e0 s\u1eed d\u1ee5ng kh\u00e1ng sinh theo kinh nghi\u1ec7m \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ea5t k\u1ef3 b\u1ec7nh \u0111\u1ed3ng nhi\u1ec5m vi khu\u1ea9n n\u00e0o. WHO s\u1ebd t\u1eadp h\u1ee3p m\u1ed9t di\u1ec5n \u0111\u00e0n g\u1ed3m c\u00e1c chuy\u00ean gia t\u1eeb kh\u1eafp n\u01a1i tr\u00ean th\u1ebf gi\u1edbi v\u00e0o ng\u00e0y 11 v\u00e0 12 th\u00e1ng 2 \u0111\u1ec3 th\u1ea3o lu\u1eadn v\u1ec1 c\u00e1ch t\u0103ng t\u1ed1c nghi\u00ean c\u1ee9u v\u1ec1 v\u1eafc-xin v\u00e0 c\u00e1c li\u1ec7u ph\u00e1p c\u00f3 th\u1ec3. Tuy nhi\u00ean, m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n \u0111ang s\u1eed d\u1ee5ng m\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ho\u1eb7c th\u1eed nghi\u1ec7m c\u00e1c b\u1ec7nh l\u00fd kh\u00e1c, trong khi \u0111\u1ed1i v\u1edbi c\u00e1c x\u00e9t nghi\u1ec7m ti\u1ec1n l\u00e2m s\u00e0ng kh\u00e1c \u0111\u00e3 b\u1eaft \u0111\u1ea7u xem x\u00e9t kh\u1ea3 n\u0103ng s\u1eed d\u1ee5ng, trong m\u1ed9t tr\u01b0\u1eddng h\u1ee3p c\u0169ng nh\u1edd v\u00e0o c\u00e1c nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n b\u1edfi Vi\u1ec7n.<\/p>\n

Remdesivir: lo\u1ea1i thu\u1ed1c n\u00e0y \u0111ang \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m tr\u00ean ng\u01b0\u1eddi ch\u1ed1ng l\u1ea1i nhi\u1ec5m Ebola v\u00e0 th\u1eed nghi\u1ec7m in vitro n\u00f3 c\u0169ng cho th\u1ea5y m\u1ed9t s\u1ed1 ho\u1ea1t \u0111\u1ed9ng ch\u1ed1ng l\u1ea1i coronavirus nh\u01b0 Sars v\u00e0 Mers. N\u00f3 \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng tr\u00ean b\u1ec7nh nh\u00e2n \u0111\u1ea7u ti\u00ean b\u1ecb nhi\u1ec5m coronavirus m\u1edbi \u1edf Hoa K\u1ef3, nh\u01b0 \u0111\u01b0\u1ee3c m\u00f4 t\u1ea3 trong Lancet, v\u00e0 c\u00e1c th\u1eed nghi\u1ec7m \u0111ang \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh tr\u00ean kho\u1ea3ng 800 b\u1ec7nh nh\u00e2n t\u1ea1i m\u1ed9t s\u1ed1 b\u1ec7nh vi\u1ec7n Trung Qu\u1ed1c.<\/p>\n

Lopinavir v\u00e0 Ritonavir: s\u1ef1 k\u1ebft h\u1ee3p c\u1ee7a hai lo\u1ea1i thu\u1ed1c ch\u1ed1ng HIV n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng v\u00e0o n\u0103m 2004 trong d\u1ecbch Sars v\u00e0 \u0111ang \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m tr\u00ean 41 b\u1ec7nh nh\u00e2n t\u1ea1i b\u1ec7nh vi\u1ec7n V\u0169 H\u00e1n, c\u00f9ng v\u1edbi m\u1ed9t li\u1ec1u alpha interferon.<\/p>\n

Chloroquine: lo\u1ea1i thu\u1ed1c ch\u1ed1ng s\u1ed1t r\u00e9t n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong h\u01a1n 70 n\u0103m v\u00e0 g\u1ea7n \u0111\u00e2y, \u1ee6y ban Y t\u1ebf Qu\u1ed1c gia Trung Qu\u1ed1c \u0111\u00e3 ch\u1ec9 ra n\u00f3 trong s\u1ed1 nh\u1eefng ng\u01b0\u1eddi c\u00f3 ho\u1ea1t \u0111\u1ed9ng in vitro ch\u1ed1ng l\u1ea1i coronavirus m\u1edbi m\u00e0 c\u00e1c x\u00e9t nghi\u1ec7m s\u1ebd ti\u1ebfp t\u1ee5c. Trong s\u1ed1 c\u00e1c nghi\u00ean c\u1ee9u \u0111\u1ea7u ti\u00ean \u0111\u1ec3 x\u00e1c minh ho\u1ea1t \u0111\u1ed9ng kh\u00e1ng retrovirus c\u1ee7a n\u00f3, trong tr\u01b0\u1eddng h\u1ee3p ch\u1ed1ng l\u1ea1i HIV, m\u1ed9t nghi\u00ean c\u1ee9u \u0111\u00e3 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n b\u1edfi c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1eeb Istituto Superiore di Sanit\u00e0 ph\u1ed1i h\u1ee3p b\u1edfi dr. Andrea Savarino.<\/p>\n

Umifenovir v\u00e0 Darunavir: tr\u01b0\u1edbc \u0111\u00e2y l\u00e0 thu\u1ed1c ch\u1ed1ng c\u00fam, c\u00f2n thu\u1ed1c sau l\u00e0 thu\u1ed1c ch\u1ed1ng HIV \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong v\u00e0i n\u0103m. C\u1ea3 hai s\u1ebd cho th\u1ea5y ho\u1ea1t \u0111\u1ed9ng ch\u1ed1ng l\u1ea1i virus trong \u1ed1ng nghi\u1ec7m.<\/p>\n

C\u00e1c giai \u0111o\u1ea1n c\u1ee7a m\u1ed9t th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng<\/strong><\/p>\n

Tr\u01b0\u1edbc khi \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t, m\u1ed9t lo\u1ea1i thu\u1ed1c tr\u1ea3i qua nhi\u1ec1u giai \u0111o\u1ea1n th\u1eed nghi\u1ec7m, c\u1ea3 ti\u1ec1n l\u00e2m s\u00e0ng v\u00e0 l\u00e2m s\u00e0ng. C\u00e1c x\u00e9t nghi\u1ec7m \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n trong \u1ed1ng nghi\u1ec7m, trong tr\u01b0\u1eddng h\u1ee3p virus tr\u00ean c\u00e1c t\u1ebf b\u00e0o b\u1ecb nhi\u1ec5m b\u1ec7nh. Nh\u1eefng ho\u1ea1t \u0111\u1ed9ng th\u1ec3 hi\u1ec7n sau \u0111\u00f3 \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m tr\u00ean c\u00e1c m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt. N\u1ebfu th\u00e0nh c\u00f4ng, ch\u00fang ta chuy\u1ec3n sang giai \u0111o\u1ea1n l\u00e2m s\u00e0ng c\u1ee7a con ng\u01b0\u1eddi, th\u01b0\u1eddng \u0111\u01b0\u1ee3c chia th\u00e0nh ba giai \u0111o\u1ea1n. \u0110\u1ea7u ti\u00ean, tr\u00ean m\u1ed9t s\u1ed1 \u00edt ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh, d\u00f9ng \u0111\u1ec3 x\u00e1c minh r\u1eb1ng thu\u1ed1c ti\u1ec1m n\u0103ng l\u00e0 an to\u00e0n v\u00e0 kh\u00f4ng g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng, v\u00e0 c\u00f3 th\u1ec3 b\u1ecf qua n\u1ebfu, v\u00ed d\u1ee5, m\u1ed9t ph\u00e2n t\u1eed \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng cho c\u00e1c m\u1ee5c \u0111\u00edch kh\u00e1c. Trong l\u1ea7n th\u1ee9 hai, li\u1ec7u ph\u00e1p \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m tr\u00ean m\u1ed9t s\u1ed1 l\u01b0\u1ee3ng b\u1ec7nh nh\u00e2n h\u1ea1n ch\u1ebf, \u0111\u1ec3 x\u00e1c minh hi\u1ec7u qu\u1ea3 c\u1ee7a h\u1ecd. N\u1ebfu giai \u0111o\u1ea1n n\u00e0y c\u0169ng \u0111\u01b0\u1ee3c th\u00f4ng qua, n\u00f3 s\u1ebd chuy\u1ec3n sang giai \u0111o\u1ea1n th\u1ee9 ba, tr\u00ean s\u1ed1 l\u01b0\u1ee3ng ng\u01b0\u1eddi b\u1ec7nh nhi\u1ec1u h\u01a1n.<\/p>\n

Ngu\u1ed3n: https:\/\/www.iss.it<\/p>\n

\n

Coronav\u00edrus, o ponto em drogas experimentais<\/strong><\/p>\n

No momento, n\u00e3o h\u00e1 terapias recomendadas pela Organiza\u00e7\u00e3o Mundial da Sa\u00fade (OMS) para o novo coronav\u00edrus, e somente as terapias de suporte s\u00e3o indicadas nas diretrizes de atendimento ao paciente, como oxigenoterapia, administra\u00e7\u00e3o de fluidos e uso emp\u00edrico de antibi\u00f3ticos para tratar qualquer co-infec\u00e7\u00e3o bacteriana. A OMS reunir\u00e1 um f\u00f3rum de especialistas de todo o mundo nos dias 11 e 12 de fevereiro para discutir como acelerar a pesquisa sobre vacinas e poss\u00edveis terapias. No entanto, alguns pacientes est\u00e3o usando alguns medicamentos j\u00e1 em uso ou experimentando outras doen\u00e7as, enquanto para outros iniciaram-se testes pr\u00e9-cl\u00ednicos em vista de um poss\u00edvel uso, em um caso tamb\u00e9m gra\u00e7as a estudos realizados pelo Instituto.<\/p>\n

Remdesivir: este medicamento est\u00e1 sendo testado em seres humanos contra infec\u00e7\u00f5es por Ebola e, em testes in vitro, tamb\u00e9m demonstrou alguma atividade contra os coronav\u00edrus, como Sars e Mers. Ele foi usado no primeiro paciente infectado com o novo coronav\u00edrus nos Estados Unidos, conforme descrito em Lancet, e est\u00e3o sendo realizados ensaios em cerca de 800 pacientes em alguns hospitais chineses.<\/p>\n

Lopinavir e Ritonavir: a combina\u00e7\u00e3o desses dois medicamentos anti-HIV foi usada em 2004 durante a epidemia de Sars e est\u00e1 sendo testada em 41 pacientes em um hospital em Wuhan, juntamente com uma dose de interferon alfa.<\/p>\n

Cloroquina: este medicamento antimal\u00e1rico est\u00e1 em uso h\u00e1 mais de 70 anos e, recentemente, a Comiss\u00e3o Nacional de Sa\u00fade da China o indicou entre aqueles que t\u00eam uma atividade in vitro contra o novo coronav\u00edrus no qual os testes continuar\u00e3o. Entre os primeiros estudos para verificar sua atividade anti-retroviral, no caso contra o HIV, um foi realizado por pesquisadores do Istituto Superiore di Sanit\u00e0, coordenado pelo dr. Andrea Savarino.<\/p>\n

Umifenovir e Darunavir: o primeiro \u00e9 um medicamento anti-gripe, enquanto o \u00faltimo \u00e9 um medicamento anti-HIV que est\u00e1 em uso h\u00e1 v\u00e1rios anos. Ambos teriam mostrado atividade contra o v\u00edrus in vitro.<\/p>\n

As fases de um ensaio cl\u00ednico<\/strong><\/p>\n

Antes de ser aprovado, um medicamento passa por v\u00e1rias fases de experimenta\u00e7\u00e3o, pr\u00e9-cl\u00ednica e cl\u00ednica. Os primeiros testes s\u00e3o realizados in vitro, no caso de v\u00edrus nas c\u00e9lulas infectadas. Aqueles que mostram atividade s\u00e3o ent\u00e3o testados em modelos animais. Se for bem-sucedido, passamos \u00e0 fase cl\u00ednica humana, que geralmente \u00e9 dividida em tr\u00eas fases. O primeiro, em um pequeno n\u00famero de pessoas saud\u00e1veis, serve para verificar se o potencial medicamento \u00e9 seguro e n\u00e3o produz efeitos colaterais s\u00e9rios, e pode ser ignorado se, por exemplo, uma mol\u00e9cula for usada e j\u00e1 estiver sendo usada para outros fins. No segundo, a terapia \u00e9 testada em um n\u00famero limitado de pacientes, para verificar sua efic\u00e1cia. Se essa fase tamb\u00e9m \u00e9 aprovada, passa para a terceira, em um n\u00famero maior de pessoas doentes.<\/p>\n

Fonte: https:\/\/www.iss.it<\/p>\n","protected":false},"excerpt":{"rendered":"

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